by The Physiological Society Our ability to regulate body temperature and keep our bodies from becoming dehydrated declines as we get older. New research published today in the Journal of Physiology improves our understanding of the relation between temperature regulation and dehydration. This research can help us to better tailor strategies for managing both body temperature regulation and hydration during heat exposure...
Concealed cardiomyopathies revealed in cardiac arrest survivors
by Centenary Institute Centenary Institute researchers have discovered that genetic testing can identify “concealed cardiomyopathies” in nearly a quarter of sudden cardiac arrest (SCA) survivors who seem to have a normal heart. The findings will mean improved diagnosis rates and personalized care for SCA survivors as well as guide the screening of family members who may have the...
Drugs aren’t typically tested on women. AI could correct that bias
CELL PRESS Researchers at Columbia University have developed AwareDX–Analysing Women At Risk for Experiencing Drug toXicity–a machine learning algorithm that identifies and predicts differences in adverse drug effects between men and women by analyzing 50 years’ worth of reports in an FDA database. The algorithm, described September 22 in the journal Patterns, automatically corrects for the...
Measuring muscle strength provides insights regarding weakness in older adults
IOS PRESS Amsterdam, NL, September 30, 2020 – Isokinetic dynamometry is a major tool in the measurement of muscle strength in the fields of sports medicine, orthopedic and neurological rehabilitation and exercise physiology. Its use in older individuals now extends far beyond orthopedics to such conditions as chronic obstructive pulmonary disease (COPD) and stroke. In...
Delirium a key sign of COVID-19 in frail, older people
KING’S COLLEGE LONDON A new analysis of data from researchers at King’s College London using information from the COVID Symptom Study app and patients admitted to St Thomas’ Hospital in London, has shown that delirium – a state of acute confusion associated with a higher risk of serious illness and death – is a key...
Cannabinoids associated with negative respiratory health effects in older adults with COPD
ST. MICHAEL’S HOSPITAL IMAGE: DR. NICHOLAS VOZORIS, A RESPIROLOGIST AT ST. MICHAEL’S HOSPITAL OF UNITY HEALTH TORONTO AND AN ASSOCIATE SCIENTIST AT THE HOSPITAL’S LI KA SHING KNOWLEDGE INSTITUTE. Cannabinoids, a class of prescription pills that contain synthetically-made chemicals found in marijuana, are associated with a 64 per cent increase in death among older adults...
Scientists map genes controlling immune system ‘brakes’
by Sarah C.p. Williams, Gladstone Institutes Unlike most T cells, which launch immune responses against foreign molecules, regulatory T cells are the peacekeepers of the human immune system, damping down inflammatory reactions when they’re not needed. Now, researchers at Gladstone Institutes, in collaboration with scientists at UC San Francisco (UCSF) and the Technical University of Munich...
Coupling antibiotics with stem cells to fight off bone infections
by Kanazawa University Protocol for implant-related infection model establishment in rats. Bone infections caused by implants are difficult to treat and usually require a prolonged course of antibiotic treatment. In a new study, researchers from Kanazawa University discovered that implant-related bone infections can be effectively treated with a combinational treatment consisting of antibiotics and antibiotic-laden stem...
Why drugs sometimes cause receptor potentiation rather than inhibition
by Ruhr-Universitaet-Bochum Using a dedicated application technique and electrophysiological measurements, the researchers rapidly activated the glutamate receptors. The picture shows a setup for patch-clamp electrophysiology. Glutamate is the messenger substance the brain uses to pass on excitatory signals. Receptors for this neurotransmitter are a promising target for drug development, as they are involved in many pathological...
COVID-19 infects majority of bad dreams: study
by Frontiers COVID-19 has turned 2020 into a nightmare for many people, as they struggle with health problems, economic uncertainty and other challenges. Now a team of researchers in Finland has evidence that the pandemic really is a bad dream. In a paper published in Frontiers in Psychology, scientists used artificial intelligence to help analyze...