by Bob Yirka , Medical Xpress An international team of researchers has developed an algorithm that can be used to predict the chances of a person with a latent Mycobacterium tuberculosis infection developing tuberculosis (TB). In their paper published in the journal Nature Medicine, the group describes surveying thousands of people from multiple countries to amass data on...
Neuropilin-1 drives SARS-CoV-2 infectivity, finds breakthrough study
by University of Bristol Neuropilin-1 (NRP1) is a host factor for SARS-CoV-2 infection. This is an image of human cells incubated with SARS-CoV-2, infected cells are labelled green. Removal of NRP1 drastically reduces SARS-CoV-2 infection in human cell cultures. Reduction of infection can also be observed when cells were treated with a drug or an antibody...
COVID-19: Distancing and masks are not enough
by Vienna University of Technology Droplets with a viral load. Wear a mask, keep your distance, avoid crowds—these are the common recommendations to contain the COVID-19 epidemic. However, the scientific foundations on which these recommendations are based are decades old and no longer reflect the current state of knowledge. To change this, several research groups from the field...
Crowd-sourcing optogenetics data to tackle neurological diseases
by Michele W. Berger, University of Pennsylvania Around the world, some 50 million people have epilepsy, with more than 3 million in the United States alone. It’s one of the most common neurological diseases globally, characterized by recurrent seizures in part or all of the body. It’s also quite treatable with daily antiseizure medications. Yet like...
Cutting cancer off at the head
by Osaka City University Scattered graph of peripheral blood of a GC patient by FACS analysis. Circulating tumor cells with FGFR2 expression were determined by FACScan using 2ml of peripheral blood. A total of 17 CTCs with FGFR2 expression was detected in peripheral blood by FACS. Osaka City University detects cancer cells in 2ml blood...
No stain? No sweat: Terahertz waves can image early-stage breast cancer without staining
OSAKA UNIVERSITY IMAGE: A SCHEMATIC DRAWING OF THE MEASUREMENT OF BREAST CANCER TISSUE FABRICATED ON A NONLINEAR OPTICAL CRYSTAL. A team of researchers at Osaka University, in collaboration with the University of Bordeaux and the Bergonié Institute in France, has succeeded in terahertz imaging of early-stage breast cancer less than 0.5 mm without staining, which is difficult...
New approach to fighting cancer could reduce costs and side effects
UNIVERSITY OF SOUTH AUSTRALIA IMAGE: CANCER CELLS ARE TARGETED BY BIOENGINEERED IMMUNE CELLS IN THE PATIENT’S SYSTEM. CAR-T biotherapeutics company Carina Biotech and researchers at the University of South Australia have developed a novel approach based on microfluidic technology to “purify” the immune cells of patients in the fight against cancer. UniSA’s Future Industries Institute PhD student...
Protein by which common skin bacteria trigger eczema identified
A decade-long study has identified the factor produced by a common species of skin bacteria that triggers eczema, in a breakthrough of our understanding of the condition. The discovery of a missing link by an international team led by University of Manchester scientists could lead to new treatments for the sometimes debilitating skin condition which...
Calcium bursts kill drug-resistant tumor cells
Multidrug resistance (MDR) – a process in which tumours become resistant to multiple medicines –– is the main cause of failure of cancer chemotherapy. Tumour cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS’ Nano Letters have developed nanoparticles that release bursts...
Study findings may help identify new targets to inhibit spread of melanoma
Reviewed by Emily Henderson, B.Sc.Oct 20 2020 Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumors at secondary sites around the body. The findings from the study may help to identify new targets to inhibit melanoma spread and guide treatment decisions in the clinic....