by National Eye Institute Detail shows structure of retina, including location of a bipolar cell expressing Nanoscope’s MCO1 opsin. A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small...
Anti-siglec-8 antibody trial shows promise for treating eosinophilic gastritis and duodenitis
by University of North Carolina at Chapel Hill School of Medicine Eosinophilic gastritis and duodenitis are inflammatory diseases characterized by high levels of eosinophils and mast cells (immune system cells) in the stomach and duodenum. These disorders are often underdiagnosed and symptoms include chronic abdominal pain and cramping, nausea, bloating, loss of appetite, vomiting and diarrhea....
Research brings understanding of cellular resistance to cancer treatment, opening doors to new cures
by Marissa Shapiro, Vanderbilt University A Vanderbilt cancer systems biology team has identified the enzymes that keep tumor cells growing in the presence of drug treatment, opening the door to stopping these cells dead in their tracks. An article, “An Integrative Gene Expression and Mathematical Flux-Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells,” was published...
New tool can diagnose strokes with a smartphone
PENN STATE IMAGE: KATHRYN ATKINSON, A PATIENT AT HOUSTON METHODIST HOSPITAL, PARTICIPATES IN A SMARTPHONE SCREENING TEST TO ANALYZE STROKE-LIKE SYMPTOMS SHE’S EXPERIENCING. THE TEST IS POWERED BY A MACHINE LEARNING ALGORITHM DEVELOPED. UNIVERSITY PARK, Pa. — A new tool created by researchers at Penn State and Houston Methodist Hospital could diagnose a stroke based on abnormalities...
COVID-19: Dexamethasone discovery carries treatment implications
UNIVERSITY OF VIRGINIA HEALTH SYSTEM IMAGE: AN ARTIST’S RENDERING OF THE DEXAMETHASONE DISCOVERY, BY MARCIN MINOR.v A new discovery about how the body transports dexamethasone, a drug that can increase the survival chances of patients with severe COVID-19, suggests diabetes and other factors may reduce its potentially lifesaving effectiveness. Based on their findings, the researchers say doctors may...
Exercising one arm has twice the benefits
EDITH COWAN UNIVERSITY IMAGE: EXERCISING ONE ARM HAS TWICE THE BENEFITS. New research from Edith Cowan University (ECU) has revealed that training one arm can improve strength and decrease muscle loss in the other arm – without even moving it. The findings could help to address the muscle wastage and loss of strength often experienced in an...
Study shows vitamin C prevents ulcer-related amputations
Ulcers are open wounds that fail to heal. They are caused or exacerbated by poor blood and nerve supply and in the case of foot ulcers, bad feet architecture. In severe cases, they can lead to amputation and there are an estimated 8,000 preventable foot amputations in Australia every year. Those, particularly at risk, are...
Toward a new staging system for prostate cancer, and why it matters
by An Demsky, University of Michigan Doctors and biostatisticians at the University of Michigan Rogel Cancer Center have led the development and validation of a staging system to better predict outcomes and inform treatment decisions for men diagnosed with non-metastatic prostate cancer. Although it is one of the most common cancers worldwide, prostate cancer remains one...
Details about broadly neutralizing antibodies provide insights for universal flu vaccine
by University of Chicago Medical Center This digitally-colorized transmission electron microscopic image depicts the ultrastructural details of an influenza virus particle. New research from an immunology team at the University of Chicago may shed light on the challenges of developing a universal flu vaccine that would provide long-lasting and broad protection against influenza viruses. The study, published October...
Common treatment for diabetic macular edema not effective in Black individuals
BOSTON MEDICAL CENTER Boston – A medication frequently used to treat diabetic macular edema, which is the most common cause of blindness in people with diabetes, is less effective when used to treat the condition in Black patients, new study results show. Led by researchers at Boston Medical Center, the study demonstrated that Black patients were significantly...