By Apoorva Mandavilli New research found ‘autoantibodies’ similar to those in lupus and rheumatoid arthritis patients. But patients may also benefit from treatments for those autoimmune diseases. Covid-19 patients were discharged from a temporary hospital in Lima, Peru, last month. The study may help explain why so-called “long-haulers” continue to experience symptoms long after the virus has left...
Researchers create millions of diverse T cells from a single blood stem cell
by Sarah C.p. Williams, University of California, Los Angeles A section of an artificial thymic organoid showing T cells (outlined in green) created from blood stem cells. Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a way to make mouse thymus organoids that can be grown in the...
Study shows FDA-approved leukemia drug may help treat metastatic melanoma
by Jenni Ho, University of Kentucky Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. A new study led by researchers at the University of Kentucky Markey Cancer Center and UK Department of Pharmacology and Nutritional Sciences demonstrates the potential benefit of using an anti-leukemic drug nilotinib—most commonly used to treat chronic myelogenous leukemia—to overcome...
‘Cinderella’ of the medicinal plant world could be the answer to better breast cancer treatment
by Royal Holloway, University of London A plant which had previously been dismissed as not being medically useful, could prove to be a hero in disguise, after scientists discovered it not only stops the growth of breast cancer cells but does not affect normal cells—a potential first for future cancer chemotherapy treatment. The ground breaking research by the...
Beetroot peptide as potential drug candidate for treating diseases
MEDICAL UNIVERSITY OF VIENNA In a recent study, a research group led by Christian Gruber at MedUni Vienna’s Institute of Pharmacology isolated a peptide (small protein molecule) from beetroot. The peptide is able to inhibit a particular enzyme that is responsible for the breakdown of messenger molecules in the body. Due to its particularly stable molecular structure...
New research shows SARS-CoV-2 spike proteins disrupt the blood-brain barrier
TEMPLE UNIVERSITY HEALTH SYSTEM IMAGE: SERVIO H. RAMIREZ, PHD, PROFESSOR OF PATHOLOGY AND LABORATORY MEDICINE AT THE LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY AND PRINCIPAL INVESTIGATOR ON THE NEW STUDY. (Philadelphia, PA) – Like a key, SARS-CoV-2 – the virus that causes coronavirus disease 2019 (COVID-19) – attaches to specific molecules on the...
Priming the immune system to attack cancer
UNIVERSITY OF PENNSYLVANIA Immunotherapies, such as checkpoint inhibitor drugs, have made worlds of difference for the treatment of cancer. Most clinicians and scientists understand these drugs to act on what’s known as the adaptive immune system, the T cells and B cells that respond to specific threats to the body. New research from an international team co-led...
Multitasking Leads to Memory Disruption Regardless of Age, Study Finds
Despite all the advances of modern civilization, the human brain remains mostly the same as it was hundreds of thousands of years ago. We humans are “built” to focus on a single analogue task at a time and then move onto the next one. And yet, with the advent of digital media, the demands made...
Wistar creates a new synthetic DNA vaccine against Powassan virus
by The Wistar Institute Powassan virus is a tick-borne, emerging infectious disease. Scientists at The Wistar Institute have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein. A rapidly reemerging tick-borne disease, POWV has been reported to be fatal in 10% of infected people with detrimental...
Scientists uncover proteins essential for memory B cell survival
by The Francis Crick Institute Signals from two key proteins are essential for the survival of our ‘immunological memory’, according to new research from scientists at the Francis Crick Institute, published in the Journal of Experimental Medicine. Memory B cells are long-lived cells that confer immunological memory by providing rapid and robust antibody responses to infections our body has seen before....