Amy Maxmen People wait to be seen at a clinic in Johannesburg, South Africa, that offers HIV drugs to treat or prevent infection.Credit: Foto24/Gallo Images/Getty An injectable drug that was lauded one year ago for being able to prevent HIV looks less perfect today, in light of a new analysis. Researchers revisited a 4,570-person clinical trial...
Scientists at the University of Virginia School of Medicine have developed a tool to monitor communications within the brain in a way never before possible, and it has already offered an explanation for why Alzheimer’s drugs have limited effectiveness and why patients get much worse after going off of them. The researchers expect their new method will...
One of the more interesting studies of cellular senescence in recent years was the demonstration that topical treatment with rapamycin, an inhibitor of mTOR signaling, over a period of months meaningfully reduced the burden of cellular senescence in the skin of aged individuals, leading to improvement in skin quality. It did not achieve this goal by directly destroying senescent cells, as rapamycin...
UTAH STATE UNIVERSITY IMAGE: SILK FIBERS ARE WOUND AROUND AN ACRYLIC CHASSIS TO PRODUCE A THREE-DIMENSIONAL CELL CULTURE DEVICE. SKELETAL MUSCLE CELLS GROWN ON SILKWORM SILK PROVED TO MORE CLOSELY MIMIC HUMAN SKELETAL MUSCLE THAN THOSE GROWN ON THE USUAL PLASTIC SURFACE. CREDIT: MATT JENSEN News Release — LOGAN, UT — Mar. 9, 2021 — Researchers at...
ROCKEFELLER UNIVERSITY PRESS IMAGE: COMPARED WITH A CONTROL (LEFT), REMOVAL OF THE MDM4 GENE (RIGHT) FAVORS THE RESOLUTION OF FIBROTIC SCAR TISSUE IN THE LUNGS OF AGED MICE. CREDIT: ©2021 QU ET AL. ORIGINALLY PUBLISHED IN JOURNAL OF EXPERIMENTAL MEDICINE. HTTPS://DOI.ORG/10.1084/JEM.20202033 Researchers at the University of Alabama at Birmingham have identified a new molecular target that could potentially...
ALPHAMED PRESS IMAGE: Autologous bone-marrow mononuclear cells were intravenously administered in patients with acute ischemic stroke as procedure outline in panel A. The non-treated patients were recruited separately. Both groups were imaged 3 time over year and neuroimaging biomarkers were developed. Integrity of the ipsilesional and contralesional cortical spinal tracts (CST) were evaluated via diffusion...
by University of California – San Diego Cancer cell during cell division. Credit: National Institutes of Health Every 12 minutes, someone in the United States dies of pancreatic cancer, which is often diagnosed late, spreads rapidly and has a five-year survival rate at approximately 10 percent. Treatment may involve radiation, surgery and chemotherapy, though often the...
by Liz Fuller-Wright, Princeton University This 3D image of human breast cancer bone metastases shows the formation of the newly described organelle (magenta) in cancer cells (cyan). Cell nuclei from both cancer cells and normal bone cells are labeled in blue. Credit: Image rendering by Mark Esposito and Gary Laevsky Some of Princeton’s leading cancer researchers were startled...
by University of Portsmouth The image depicts myelin (Cyan) and specialised brain stem cells Oligodendrocyte Progenitor Cells (OPCs) in the grey and white matter of the brain. Myelin is an insulation produced by cells called Oligodendrocytes, which are in turn produced by OPCs. The nuclei of all the cells in the brain are shown in blue....
by Katherine Fenz, Rockefeller University Graphical Abstract. Credit: Cell (2020). DOI: 10.1016/j.cell.2020.10.046 Just because you are exposed to a pathogen does not mean you will become sick. Increasingly, scientists have shown that genetics play a central role in determining whether the pathogens that cause a wide range of disease—including influenza, warts and COVID-19—end up causing serious diseases. The...
