by Bill Hathaway, Yale University Axons extending from the eye (left) to the brain (right) in the optic nerve after the nerve has been crushed. In the control, untreated case (top) very few nerve fibers succeed in growing back. After suppression of Interlukin-22 (Il22) in the retina, many more axons can regenerate from the injury. Credit:...
by The Mount Sinai Hospital James Murrough, MD, PhD, Director of the Depression and Anxiety Center for Discovery and Treatment at the Icahn School of Medicine at Mount Sinai. Credit: Mount Sinai Health System Researchers from the Icahn School of Medicine at Mount Sinai have identified a drug that works against depression by a completely different mechanism...
by University of California – San Diego Newly developed brain maps with unprecedented detail are helping answer critical questions about brain blood flow. These new maps offer resolution finer than a millionth of a meter, reconstructed here with high microvessel density areas in red, intermediate density areas in white and low density areas in blue. Credit:...
by National Research Council of Science & Technology KMxG red ginseng manufactured through microwave processing. Credit: Korea Institute of Science and Technology (KIST) Red ginseng, which has long been used as an ingredient in traditional Korean medicine, has recently drawn increased attention as a functional material for its health-promoting effects. The composition and activities of red ginseng...
by Osaka City University (A) The neuroprotection by sesaminol. ARE: antioxidant response element, EpRE: electrophile responsive element, ROS: reactive oxygen species, NQO1: NAD(P)H: quinone oxidoreductase, HO-1: hemo oxygenase-1, ?-GCS:??-glutamylcysteine synthetase(B) Effects of sesaminol and 6-OHDA on the viability of SH-SY5Y cells.SH-SY5Y cells were incubated with 0.25~10 ?g/ml of sesaminol for 2 h, followed by treatment...
by Griffith University The three-dimensional structure of the SARM1 protein determined by cryo-electron microscopy. Credit: Jeff Nanson. A Griffith University-led research team has discovered how a therapeutic target common among debilitating neurodegenerative disorders is activated, which could help accelerate drug development. In a study published in the journal Neuron, the researchers from Griffith University’s Institute for Glycomics, the...
by Children’s Hospital of Philadelphia Credit: CC0 Public Domain Researchers from the Mitochondrial Medicine Frontier Program at Children’s Hospital of Philadelphia (CHOP) have demonstrated how one combination of therapies may be beneficial for patients with mitochondrial respiratory chain disorders. This preclinical research paves the way to develop more tailored treatment options for patients with inherited mitochondrial disease and acquired...
By Jocelyn Kaiser Mar. 1, 2021 , 11:00 AM Researchers have shown in mice that designer antibodies can curb the growth of tumors by targeting two of cancer’s most infamous offenders—the proteins RAS and p53, which are mutated in many tumors but have largely defied drug development efforts. If their promise holds up in clinical trials,...
Holding off the rise of superbugs could be achieved by ‘resuscitating’ old antibiotics, with The University of Queensland researchers leading an international project to help combat the growing threat. CARB-X, a global non-profit partnership funding the world’s largest antibacterial development pipeline, has funded the $AU2.9m project at UQ’s Institute for Molecular Bioscience (IMB). Drs Mark Blaskovich, Alysha Elliott and Johanne...
Researchers from the University of Oxford and the University of Hamburg have discovered a disease-causing population of immune cells, which travel to the brain in patients with multiple sclerosis (MS). Using an approved treatment, which blocks transit through the blood brain barrier, they demonstrate how to trap these cells in the blood, revealing a unique opportunity...
