Imagine if surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries. And imagine if they could “grow” these neurons in the laboratory from a patient’s own cells using a synthetic, highly bioactive material that is suitable for 3D printing. By discovering a new printable biomaterial that can...
Individualized brain cell grafts reverse Parkinson’s symptoms in monkeys
Grafting neurons grown from monkeys’ own cells into their brains relieved the debilitating movement and depression symptoms associated with Parkinson’s disease, researchers at the University of Wisconsin–Madison reported today. In a study published in the journal Nature Medicine, the UW team describes its success with neurons made from induced pluripotent stem cells from the monkeys’ own...
The doctor will sniff you now
It’s 2050, and you’re due for your monthly physical exam. Times have changed, so you no longer have to endure an orifices check, a needle in your vein, and a week of waiting for your blood test results. Instead, the nurse welcomes you with, “The doctor will sniff you now,” and takes you into an...
Potential drug for Alzheimer’s disease prevention found safe and effective in animals
ROCKEFELLER UNIVERSITY PRESS IMAGE: Compared with a control (left), treatment with the novel GSM (right) reduces the number of amyloid plaques (green) and proinflammatory cells called microglia (magenta) in the brains of mice carrying mutations linked to early-onset Alzheimer’s disease. CREDIT: ©2021 RYNEARSON ET AL. ORIGINALLY PUBLISHED IN JOURNAL OF EXPERIMENTAL MEDICINE. HTTPS://DOI.ORG/10.1084/JEM.20202560 Researchers at the University of...
HKBU develops dual-targeting drug for EBV-related cancers
HONG KONG BAPTIST UNIVERSITY IMAGE: A research team led by Professor Gary Wong Ka-Leung (centre), Dr Lung Hong Lok (right) and Dr Law Ga-lai develop a novel dual-targeting drug for treating cancers associated with EBV. CREDIT: HONG KONG BAPTIST UNIVERSITY A Hong Kong Baptist University-led (HKBU) research team has developed a novel drug which has the potential...
A mechanism by which cells build ‘mini-muscles’ underneath their nucleus identified
UNIVERSITY OF HELSINKI IMAGE: On the left: Super-resolution microscopy image of a migrating human osteosarcoma cell. Magenta marks focal adhesions, and green non-muscle myosin II (NMII). F-actin bundles are shown in grey. On the right: Schematics of cortical stress ?ber assembly process. Myosin II pulse orchestrates the initial assembly and maturation of a cortical stress...
A new theory for how memories are stored in the brain
by University of Kent Credit: Unsplash/CC0 Public Domain Research from the University of Kent has led to the development of the MeshCODE theory, a revolutionary new theory for understanding brain and memory function. This discovery may be the beginning of a new understanding of brain function and in treating brain diseases such as Alzheimer’s. In a...
Why some melanoma patients do not respond to immunotherapy
by Columbia University Irving Medical Center Credit: Pixabay/CC0 Public Domain By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients—across cancer types—do not respond, and in most cases, scientists are at a loss as to why. Researchers at Columbia and MIT have created a new technique...
Scientists develop vaccine strategy for urinary tract infections
by Duke University Medical Center Immune cells (green) infiltrating the bladder lining (red) to fight off invading bacteria. Blue areas are nuclei of other bladder tissue cells. Credit: Duke Health Anyone who has ever developed a urinary tract infection (UTI) knows that it can be painful, pesky and persistent. UTIs have a high recurrence rate and...
Predicting microbial interactions in the human gut
by Ananya Sen, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign Graduate student Veronika Dubinkina of Bioengineering, Professor of Bioengineering and Bliss faculty scholar Sergei Maslov, MIT postdoctoral fellow Akshit Goyal, and graduate student Tong Wang of Physics. Credit: Julia Pollack, University of Illinois The human gut consists of a complex...