ETH ZURICH IMAGE: LEFT: CONVENTIONAL FLUORESCENCE IMAGES OF A MOUSE BRAIN. RIGHT: AN IMAGE TAKEN WITH THE NEW DIFFUSE OPTICAL LOCALIZATION IMAGING (DOLI) METHOD. CREDIT: ETH ZURICH, UNIVERSITY OF ZURICH / DANIEL RAZANSKY The way the human brain works remains, to a great extent, a topic of controversy. One reason is our limited ability to...
by University of Rochester Medical Center Fig. 1 Schematic of the Cas9 RNP delivery system. (A) Lipidoid nanoparticle (LNP)–encapsulated Cas9 RNP delivery system. PCL nanofibril (NF) that mimic the bone tissue environment were coated with mesenchymal stem cell membrane (MSCM) and were loaded with CXCL12α cytokine and LNP-coated Cas9 RNP. (B) The LNP-Cas9 RNP/MSCM-NF/CXCL12α complex can...
by Menzies School of Health Research Credit: Menzies School of Health Research Groundbreaking studies published today in the New England Journal of Medicine and PLOS Medicine have found large numbers of malaria parasites hiding in the human spleen where they actively multiply in a previously unrecognized life cycle. Until now, it was thought that once malaria parasites reached the blood stream,...
by University of Minnesota A team of researchers, led by University of Minnesota associate professor Chun Wang, have engineered a polymer “wafer” (pictured above) that, when placed under the tongue, can effectively deliver and preserve protein-based vaccines for diseases. Credit: Polymeric Biomaterials Lab, University of Minnesota A team of researchers, led by a University of Minnesota associate...
by Columbia University A peptide that stimulates receptors in neurons reduced the amount of toxic tau proteins present. Tau proteins are labeled yellow. Left image shows untreated neurons; right image shows neurons treated with the peptide. Credit: Natura Myeku A new idea for treating Alzheimer’s disease could eradicate the toxic proteins most closely linked to cognitive decline in...
by Leigh MacMillan, Vanderbilt University Credit: CC0 Public Domain Patients with autonomic failure—a neurodegenerative disorder characterized by a disabling drop in blood pressure on standing (orthostatic hypotension, OH)—commonly have increased blood pressure when lying down. This supine hypertension, which is difficult to manage overnight, is associated with end-organ damage and can worsen daytime OH. Luis Okamoto,...
by Northwestern University Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: Wikipedia A team of Northwestern Medicine scientists led by Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, has identified the molecular mechanisms of ASXL1 mutations involved in leukemia pathogenesis, according to a study...
by University of Miami Leonard M. Miller School of Medicine Credit: Pixabay/CC0 Public Domain Poor sleep impacts the risk of long-term cognitive decline in Hispanic/Latino middle aged and older adults differently than it does in non-Hispanic adults, according to research led by University of Miami Miller School of Medicine neurology faculty and the largest long-term study...
by Flinders University Credit: CC0 Public Domain Men aged 65 and over should monitor their sleep patterns and seek medical advice after a warning from Flinders University experts that disrupted slumber can be linked to cognitive dysfunction. In a new article published in the Journal of Sleep Research, the Adelaide Institute for Sleep Health research group studied a group of...
by University of Southampton Credit: University of Southampton Innovative in-sole sensors will alert diabetic patients during excessive or extended activities that could trigger foot ulcers in a new system being developed at the University of Southampton. The LOad Monitoring and Intervention System (LOMIS) processes real-time data from three directional force sensors and detects physical activities over...
