by Nottingham Trent University Graphical abstract. Credit: DOI: 10.1016/j.freeradbiomed.2021.08.233 A large proportion of the damaging chemical changes which occur in the body’s cells due to diabetes and obesity could be prevented by a naturally occurring molecule, a new study suggests. In type 2 diabetes, when glucose stays in the blood it is not used as fuel for...
by Mette Haagen Marcussen, Technical University of Denmark Fig. 1: Experimental overview of our scMS workflow. a Overview of the hierarchical nature of an Acute Myeloid Leukemia hierarchy, with leukemic stem cells (LSC) at the apex, differentiating into progenitors, and subsequently, blasts. b FACS plot of the OCI-AML8227 hierarchy according to their CD34/CD38 surface marker expression...
by University of Kent Credit: Pixabay/CC0 Public Domain New research has revealed the differences in mechanism behind cancer’s resistance to the major class of anti-cancer drugs known as nucleoside analogs. Nucleosides are molecules containing the genomic information that can be chemically modified into so-called nucleoside analogs to cause them to inhibit DNA formation in cancer cells, causing the...
by National University of Singapore Retinal progenitor cells derived from RxCell induced pluripotent stem cells (iPSCs) can mature into retina photoreceptors after transplantation into the preclinical models, enabling restored vision. Credit: NUS Yong Loo Lin School of Medicine. Inherited retinal diseases (IRDs) are a group of genetically and clinically homogeneous illnesses characterized by progressive retinal damage...
by Ludwig Institute for Cancer Research Credit: Unsplash/CC0 Public Domain A Ludwig Cancer Research study has identified and preclinically validated combination treatments for the brain metastases of breast cancer, a common and typically lethal manifestation of the malignancy. The combination therapy, reported in the current issue of Nature Cancer, targets tumor-associated macrophages and microglia (TAMs), immune cells...
by Lauran Neergaard This Thursday, Feb. 25, 2021 file photo shows vials for the Moderna and Pfizer COVID-19 vaccines at a temporary clinic in Exeter, N.H. In September, 2021, the Food and Drug Administration approved extra doses of Pfizer’s original COVID-19 vaccine after studies showed it still works well enough against the delta variant. And...
by University of New England Credit: Unsplash/CC0 Public Domain Glenn Stevenson, Ph.D., professor of psychology within the School of Social and Behavioral Sciences at UNE, recently published a paper on gut microbiome modulation of inflammatory pain. The paper, “Effects of vancomycin on persistent pain-stimulated and pain-depressed behaviors in female Fischer rats with or without voluntary access...
A new study, published in the journal Menopause, characterizes cycle-length changes over the menopause transition and found that women whose cycle increased in length two years before their final menstrual period had better measures of vascular health than those who had stable cycle lengths during this transition. In combination with other menopause-related characteristics and health measures,...
(HealthDay)—Receipt of the Ad26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccine is associated with a potential small, but statistically significant, safety concern for Guillain-Barré syndrome (GBS), according to a study published online Oct. 7 in the Journal of the American Medical Association. Emily Jane Woo, M.D., M.P.H., from the U.S. Food and Drug Administration in Silver Spring, Maryland,...
(HealthDay)—Biologic therapies are available for pediatric patients with asthma and allergic skin diseases, according to a clinical report published online Oct. 18 in Pediatrics. Heather Hoch De Keyser, M.D., from the University of Colorado Anschutz, and colleagues reviewed the current literature on biologics in the treatment of children with asthma and allergic skin disease. The authors note that...
