by Wellcome Trust Sanger Institute Credit: CC0 Public Domain Cells carrying mutations can out compete early tumors in the mouse esophagus, so they never make it into cancers, new research has shown. Normal human esophagus is a patchwork of cells containing mutations, known as mutant clones. This new research, from the Wellcome Sanger Institute, the University...
by University of Pittsburgh John Mellors, M.D. Credit: UPMC For nearly a decade, scientists have known that HIV integrates itself into genes in cells that have the potential to cause cancer. And when this happens in animals with other retroviruses, those animals often develop cancer. But, perplexingly and fortunately, that isn’t regularly happening in people living...
by Marcela Quintanilla Dieck, Massachusetts General Hospital Graphical abstract. Credit: DOI: 10.1016/j.celrep.2021.109785 A central feature of type 2 diabetes is an inability of the body’s cells to respond to insulin, a hormone that keeps blood glucose levels normal. Critical to this balance is the liver, which both stores and manufactures glucose depending on the body’s need....
by Chinese Academy of Sciences Preparation of macrophage–tumor chimeric exosomes and tumor inhibition mechanism. Credit: WEI Wei Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed macrophage–tumor chimeric exosomes that co-activate the immune response and tumor microenvironment to support cancer immunotherapy. Their study was published in Science Translational Medicine on Oct....
by University at Buffalo Credit: CC0 Public Domain The use of heartburn medication is associated with decreased severity of gum disease, according to a recent University at Buffalo study. The research found that patients who used proton pump inhibitors (PPIs)—a class of drugs commonly prescribed to treat heartburn, acid reflux, and ulcers—were more likely to have...
by Focused Ultrasound Foundation MR images showing reduction in size of metastatic tumors after focused-ultrasound delivery of antibody therapy through blood-brain barrier. Credit: Sunnybrook Health Sciences Centre In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver...
Researchers used data on diet and mental health collected from more than 24,000 US adults between 2005 and 2016 and found that people who ate mushrooms had lower odds of having depression. According to the researchers, mushrooms contain ergothioneine, an antioxidant that may protect against cell and tissue damage in the body. Studies have shown...
by Candice Choi This Jan. 23, 2014 file photo shows the nutrition facts label on the side of a cereal box in Washington. Food companies are coming under renewed pressure to use less salt after U.S. regulators spelled out target sodium levels for dozens of foods including condiments, french fries, and potato chips. Credit: AP...
Tom Edwardson modified a tiny artificial protein structure so it could be used as a vehicle for RNA molecules and other active substances. He now aims to create a spin-off to bring his development to market. Tom Edwardson holds up a 3D-printed model of his protein cage. The actual cages are three million times smaller....
This paper is interesting as a first step on the way to further research into compensatory therapies that can reduce the cardiac muscle dysfunction of heart failure. One-time radiation therapyappears to persistently change cardiomyocyte behavior via altered epigenetic regulation of notch signaling, leading to modestly improved heart tissue function. Perhaps this should be taken as supportive of efforts to more directly target this regulatory pathway in...
