by Will Doss, Northwestern University Machine-learning model can detect rare cardiomyopathy Time course of non-cardiac and cardiac phenotypes associated with wild-type ATTR cardiomyopathy vs. non-amyloid heart failure prior to the diagnosis of heart failure. The proportion of patients at each time point (years before heart failure diagnosis) with a first diagnosis of an associated feature...
Month: <span>October 2021</span>
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New avenues for the optimisation of dendritic cell-based cancer immunotherapies
by University of Helsinki Artistic rendering of the surface of a human dendritic cell illustrating sheet-like processes that fold back onto the membrane surface. Credit: National Institutes of Health (NIH) A recent study from the University of Helsinki reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the...
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Clinical feasibility of individualized therapy in leukemia and lymphoma patients
by Johannes Angerer, Medical University of Vienna Figure S1. Sunburst plot showing the classes of drugs tested by scFPM. Drugs can be broadly classified into kinase inhibitors, immunomodulatory drugs, epigenetic modifiers, metabolic modifiers, apoptotic modulators, classical chemotherapeutics and other drugs. Credit: DOI: 10.1158/2159-8290.CD-21-0538 Standard therapy for advanced recurring aggressive, hematological malignancies, such as leukemias and lymphomas,...
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At-home cognitive assessment performs as well as widely used, clinician-led test
by Baycrest Centre for Geriatric Care Credit: Pixabay/CC0 Public Domain The Baycrest-developed, at-home Cogniciti Brain Health Assessment performs as well as a widely used, clinician-led test at assessing patients’ cognitive health, reports a new study. The Brain Health Assessment is as accurate as the widely used Montreal Cognitive Assessment (MoCA) at identifying problems with memory and...
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Patients with kidney transplants more vulnerable to common, usually harmless bacterium
by Medical College of Georgia at Augusta University Credit: CC0 Public Domain It’s a pervasive bacterium found in soil and water that rarely causes disease, but a new national review of nocardia infection in people who have had a kidney transplant shows that when it occurs it most commonly causes pneumonia and brain abscess, and reminds...
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Moderna has no plans to share its COVID-19 vaccine recipe
by Frances D’emilio Moderna co-founder and chairman Noubar Afeyan listens to questions during an interview with the Associated Press, in Rome, Monday, Oct. 11, 2021. Credit: AP Photo/Andrew Medichini Moderna has no plans to share the recipe for its COVID-19 vaccine because executives have concluded that scaling up the company’s own production is the best...
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Precision medicine data dive shows water pill may be viable to test as Alzheimer’s treatment
by National Institutes of Health PET scan of a human brain with Alzheimer’s disease. Credit: public domain A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer’s disease treatment for those who are at genetic risk, according to findings published in Nature Aging. The research...
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Engineers report advance in rapid cancer detection and monitoring
by Laurie Fickman, University of Houston Credit: Unsplash/CC0 Public Domain When it comes to cancer detection, size matters. Traditional diagnostic imaging cannot detect tumors smaller than a certain size, causing missed opportunities for early detection and treatment. Circulating tumor exosomes are especially small cancer biomarkers and easy to miss. These nanovesicles are composed of molecules that...
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Treating Anal Cancer Precursor Lesions Reduces Cancer Risk for People With HIV
Groundbreaking National Clinical Trial Halted Due to Therapy’s High Success Rates. Treating precursor anal cancer lesions can significantly reduce the risk of progression to full blown anal cancer among people living with HIV, according to results of a large, phase 3 study led by researchers at UC San Francisco. In a randomized clinical trial with...
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Mouse experiments with a decades-old drug suggest a new approach to Alzheimer’s treatment
By Megan Molteni Oct. 11, 2021 Reprints ADOBE Ageneric drug used widely to treat swelling associated with hypertension and heart failure showed hints in early research that it may also prevent the devastating brain damage of Alzheimer’s disease, a surprising twist that suggests scientists have a lot more to learn about the root cause of the...