by Innovation Center of NanoMedicine Glucose-PEGylated avelumab prevented the growth of glioblastoma. Credit: 2021 Innovation Center of NanoMedicine Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering....
by Liu Jia, Chinese Academy of Sciences Credit: Public Domain Depression, a common mental disorder, can severely disturb the life of its patients. A hypothesis stated that the excitatory synapses characterized by the post-synaptic density (PSD) in the hypothalamus, which played a crucial role in emotion regulation, may be involved in the pathogenesis of depression. However,...
by Massachusetts General Hospital Cancer — Histopathologic image of colonic carcinoid. Credit: Wikipedia/CC BY-SA 3.0 Immune checkpoint inhibitors, which unleash the immune response against tumor cells, have revolutionized cancer treatment; however, the medications aren’t effective in a large number of patients, including those with colorectal cancer. New research published in PNAS that was led by investigators at Massachusetts...
The gut microbiome is important in health and aging. Populations of microbes change with age, favoring harmful inflammatory populations at the expense of populations that generate beneficial metabolites. Restoration of a youthful microbiome via fecal microbiota transplantation has been demonstrated to be beneficial in animal studies. The research community is also evaluating other approaches to at least partially rejuvenate the aged gut microbiome,...
IMPACT JOURNALS LLC IMAGE: RELATIVE EXPRESSION OF EXOSOMAL AND NON-EXOSOMAL MIRNAS NORMALIZED TO THE CORRESPONDING MIRNA-16-5P (UPPER RAW) AND NORMALIZED AS EXOSOMAL TO NON-EXOSOMAL MIRNAS RATIO (LOWER RAW) IN SALIVA OF PATIENTS WITH HCV-RELATED CIRRHOSIS (STUDY GROUP 1, N = 24), LIVER CANCER (STUDY GROUP 2, N = 24) AND HEALTHY VOLUNTEERS (CONTROL GROUP, N...
by Queen Mary, University of London Figure S1A. Principal Component Analysis (PCA) of cell line phosphoproteomic data. PCA demonstrates distribution of data according to cell line (intra-hepatic cholangiocarcinoma (CCA) (HuH-28, KKU-213, HuCCT1, OZ), extra-hepatic CCA (CCC-5, TFK-1, EGI-1), gallbladder cancer (TGBC24TKB, TGBC1TKB), benign biliary (MMNK-1) and benign epithelial (MCF-10A). Credit: DOI: 10.1158/0008-5472.CAN-21-0955 Researchers at King’s College...
Credit: Pixabay/CC0 Public Domain Vaccination is highly effective at preventing severe cases of COVID-19, even against the Delta variant, a vast study in France has shown. The research published Monday—focusing on prevention of severe COVID and death, not infection—looked at 22 million people over 50 and found those who had received jabs were 90 percent...
When Hispanic people get a skin cancer diagnosis, their tumors are about 17% larger than those of white people, researchers say. According to the American Academy of Dermatology (AAD), skin cancer is often diagnosed at a more advanced stage in people with black and brown skin, leading to worse results. This makes it especially important to know the signs...
by German Center for Neurodegenerative Diseases Credit: CC0 Public Domain Researchers at the DZNE and the University Medical Center Göttingen (UMG) have identified molecules in the blood that can indicate impending dementia. Their findings, which are presented in the scientific journal EMBO Molecular Medicine, are based on human studies and laboratory experiments. University hospitals across Germany were...
by University of Oxford Figure 1. Genome wide haploid genetic screen identifies genes necessary for the activity of 3′-dA and NUC-7738. A) Number of unique gene trap sense insertions and significant gene hits found in the haploid genetic screen. B) Venn diagram indicating the overlap of significant hits found for NUC-7738 treatment. Credit: 10.1158/1078-0432.CCR-21-1652 A new...
