TECHNICAL UNIVERSITY OF MUNICH (TUM) IMAGE: PROF. ACHIM KRÜGER AND HIS TEAM AT TUM’S UNIVERSITY HOSPITAL KLINIKUM RECHTS DER ISAR HAVE IDENTIFIED THE PROTEIN TIMP1 AS A FACTOR, WHICH CAN EXPLAIN THE SEX-SPECIFIC DIFFERENCE IN CANCER MORTALITY AND ALSO IMPROVE THE RISK-DIAGNOSTICS FOR THE CLINICAL COURSE OF THE DISEASE. THE IMAGE SHOWS PROF. KRÜGER, CELINA...
IMAGE: (A) WESTERN BLOT ANALYSIS OF MYC IN INDICATED CELL LINES AFTER TRANSFECTION WITH 10 NMOL/L OF MIR-NC OR MIR-766-5P. THE INTENSITY OF MYC BANDS WAS QUANTIFIED BY DENSITOMETRY AND SHOWN AS THE FOLD CHANGE AFTER NORMALIZATION WITH Β-ACTIN. NA, NOT APPLICABLE. (B) WESTERN BLOT ANALYSIS OF CBP AND BRD4 IN HCT116-/- CELLS 48 HOURS...
by Johannes Angerer, Medical University of Vienna In DNMT1 deficient keratinocytes, DNA hypomethylation induces transposon derepression, mitotic defects and formation of micronuclei. DNA released into the cytosol by micronulear rupture activates signaling through cGAS and STING, further activating inflammation by ISG induction. Credit: DOI: 10.15252/embj.2021108234 The innate human immune system is capable of recognizing and fighting...
by Swinburne University of Technology Credit: Pixabay/CC0 Public Domain Researchers from the Swinburne Anorexia Nervosa (SWAN) Research Group have discovered what is believed to be the first biomarker for anorexia nervosa. Biomarkers are typically used in the detection and treatment of physical illnesses, but never before have they been used in mental disorders. The challenges of diagnosis Anorexia nervosa...
by C. Michael White, The Conversation Credit: Unsplash/CC0 Public Domain Different people taking the same drug can have markedly different responses to the same dose. While many people will get the intended effects, some may get little to no benefit, and others may get unwanted side effects. As a pharmacist who researches the safety and effectiveness of drugs, I know there are...
by Massachusetts Eye and Ear Infirmary Credit: Unsplash/CC0 Public Domain A team of Mass Eye and Ear Scientists led by Albert Edge, Ph.D., working with research fellow Yushi Hayashi, MD, Ph.D., has identified the mechanism that can lead to deafness in the rare syndrome, Norrie disease. The researchers found that the Norrie Disease Protein (NDP), which...
by United European Gastroenterology Credit: Pixabay/CC0 Public Domain Around 11 percent of the global population (13 percent of women and 9 percent of men) frequently experience abdominal pain when they eat meals, according to a survey on over 50,000 people. The research is being presented for the first time today at UEG Week Virtual 2021. Pain associated...
by Griffith University Credit: Pixabay/CC0 Public Domain Personalized nutrition advice from primary healthcare providers including General Practitioners is better than usual care at improving a person’s health and costs little more, a Griffith University study has found. Researchers from Griffith’s Healthy Primary Care team conducted an international review of published health studies from the UK, Ireland, Western Europe, The...
by Will Doss, Northwestern University Adult-born neurons in a section of the dentate gyrus. Red, green and yellow neurons are labeled with different markers. Blue outlines the dentate gyrus where mature neurons are located. Credit: Northwestern University A unique interaction between an excitatory neural receptor and a chloride transporter are critical for development of adult-born neurons...
by University of Sydney Cannabigerolic acid (CBGA), cannadivarinic acid (CBDVA), cannabidivarin (CBDV) and cannabigerovarinic acid (CBGVA) reduce seizures in a mouse model of intractable epilepsy. Credit: University of Sydney Research from pharmacologists at the University of Sydney provides new insights into how cannabis extracts may work to treat epilepsy. The study for the first time reports that...
