Exoskeleton devices work, researchers say, for a variety of uses such as speeding up our walking or making running easier. Yet they don’t know what exactly makes exoskeletons effective. What is the benefit of customization, for example? And how much does simply getting used to the exoskeleton matter? “People are amazing at learning new tasks,”...
Month: <span>October 2021</span>
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Patients with rare scleroderma have deadlier organ damage, despite getting standard treatment
A Michigan Medicine-led study found that patients in the United States with a rare form of scleroderma have a greater chance of dying from related kidney, heart, and lung problems, despite taking medications used to treat most patients with the disease. The research team assessed more than 300 patients diagnosed with, or at risk for,...
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Is Iron Metabolism an Understudied Aspect of Aging?
Many of the interventions demonstrated to produce interesting effects on the pace or state of aging are challenging to learn from. This is the case because these interventions change so much of the operation of metabolism as to make it hard to pick apart what is most relevant to the progression of aging versus what...
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Impaired vision increases risk of depression in midlife women
THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS) CLEVELAND, Ohio (Oct. 27, 2021)—Midlife women are known to have the highest prevalence of depression compared with all other age groups, and women have higher depression rates than men. A new study suggests that midlife vision impairment is associated with increased odds of future depressive symptoms for midlife women....
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Carbon nanotube-based sensor can detect SARS-CoV-2 proteins
Anne Trafton | MIT News OfficePublication Date: October 26, 2021 Caption: Using specialized carbon nanotubes, MIT engineers have designed a novel sensor that can detect SARS-CoV-2 without any antibody, giving a result within minutes. Credits:Images: courtesy of the researchers Using specialized carbon nanotubes, MIT engineers have designed a novel sensor that can detect SARS-CoV-2 without...
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Pyruvate as an essential substance for the survival of neurons and Schwann cells under high-glucose milieu
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE IMAGE: RAPID AND EXTENSIVE SCHWANN CELL DEATH UNDER HIGH-GLUCOSE PYRUVATE-DEPLETED CONDITIONS CAN BE EVOKED BY THE FOLLOWING SEQUENTIAL METABOLIC ALTERATIONS; 1) DIMINISHED TCA CYCLE INTERMEDIATES AND MITOCHONDRIAL ATP PRODUCTION, 2) REDUCED GAPDH ACTIVITY AND INHIBITION OF GLYCOLYTIC FLUX THROUGH THE ACTIVATION OF PARP, 3) ESCALATION OF THE POLYOL AND...
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Four commonly used medications reverse Alzheimer’s disease in mice
INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) IMAGE: DESCRIPTION OF THE EXPERIMENTAL FLOWCHART CREDIT: IRB BARCELONA Barcelona, 27 October 2021,- Alzheimer’s disease is the most common cause of dementia in Western societies and it is estimated that 24 million people worldwide have this condition. ICREA researcher Dr. Patrick Aloy, head of the Structural Bioinformatics and Network...
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Membrane vesicles studied as carcinoma treatment
KAZAN FEDERAL UNIVERSITY IMAGE: (A) IMMUNOPHENOTYPE OF NATIVE NEWLY ISOLATED HADSCS (PASSAGE 1). CELLS WERE POSITIVE FOR CD29, CD44, CD73, CD90, CD105, AND NEGATIVE FOR (NEGATIVE CONTROL) CD11B, CD19, CD34, CD45, AND HLA-DR. (B, C) OSTEOGENIC, ADIPOGENIC, AND CHONDROGENIC DIFFERENTIATION OF HADSCS. PHASE CONTRAST MICROSCOPE IMAGES. TO DIFFERENTIATE TOWARD ADIPOGENIC LINEAGE NATIVE HADSCS WERE CULTURED...
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Picomolar antimalarial agent from a Chinese medicinal plant
IMAGE: PICOMOLAR ANTIMALARIAL AGENT FROM A CHINESE MEDICINAL PLANT CREDIT: ©SCIENCE CHINA PRESS Dimeric sesquiterpenoids (DS), particularly the dimeric lindenane sesquiterpenoids dimers (DLS), featuring a basic scaffold by a [4 + 2] endo Diels–Alder reaction of two lindenane sesquiterpenoid monomers, are the characteristic components that occur mainly in the Chloranthus and Sarcandragenera. Shizukaol A from Chloranthus japonicus was the first...
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New life for a cancer drug that reprograms pain pathways to treat chronic pain
IMAGE: UPPER RIGHT: SCREENING COMPOUNDS IN THE “JUNKYARD OF CANCER DRUGS”, AKIN TO SIEVING THROUGH SAND, LOOKING FOR GOLD NUGGETS. KENPAULLONE WAS IDENTIFIED AS A PROMISING CANDIDATE OWING TO ITS ABILITY TO SWITCH ON THE KCC2 GENE, WHICH HAS BEEN PREDICTED TO ALLEVIATE CHRONIC PAIN. UPPER LEFT: INTRACTABLE CHRONIC PAIN IS A SERIOUS AND PRESSING...