Month: <span>February 2022</span>

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Targeting TGF-β for treatment of osteogenesis imperfecta
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Targeting TGF-β for treatment of osteogenesis imperfecta

by Molly Chiu, Baylor College of Medicine Figure 1. Transcriptomic and bioinformatics analyses demonstrate activation of TGF-β signaling in OI type III bone. (A) Principal component analysis (PCA) plot of transcriptomic data from non-OI and OI type III bones in 3-PC dimensions. (B) Hierarchical clustering based on Euclidian distance using RPKM of all non-OI and...

Scientists discover how caffeine protects against cardiovascular disease
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Scientists discover how caffeine protects against cardiovascular disease

by McMaster University A The effect of caffeine (CF; 200 µM) on SREBP2 and SREBP1 mRNA expression was examined in primary mouse hepatocytes (PMH) in the presence and absence of thapsigargin (TG; 100 nM), an established activator of SREBPs. The downstream product of SREBP2 transcriptional activity, HMGR, was also examined. B, C The inhibitory effect of CF...

Omicron-targeted vaccines do no better than original jabs in early tests
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Omicron-targeted vaccines do no better than original jabs in early tests

Emily Waltz Ambulances queue at a London hospital during a COVID-19 surge driven by the Omicron variant. Credit: Mark Thomas/Shutterstock As the Omicron variant of SARS-CoV-2 continues its global rampage, vaccine makers are pouring resources into clinical trials of COVID-19 shots tailored to the highly transmissible variant. But a raft of early animal studies suggest...

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1 IN 16 WOMEN TAKE HARMFUL MEDICATIONS WHILE PREGNANT

Teratogenic drugs can cause pregnancy loss, birth defects, and other health problems for the unborn child. The new findings highlight the need for women and their providers to carefully examine medications taken during pregnancy. “If you are pregnant, planning to become pregnant, or sexually active you must understand the risks involved with taking teratogenic drugs,”...

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Seeing Is Believing – Mapping How Cell Types and Tissues Develop

Researchers have developed a technique that allows them to look simultaneously at a spatial level and at a genome-wide level at epigenetic mechanisms underlying tissue development, a breakthrough with multiple scientific and medical applications.   While current technologies allow scientists to examine epigenetic information in the bulk of a tissue, and recent breakthroughs further extend to an individual...

Lab-Designed “Fish” Could Pave the Way for Artificial Hearts
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Lab-Designed “Fish” Could Pave the Way for Artificial Hearts

FEBRUARY 15TH, 2022   CONN HASTINGS  CARDIAC SURGERY, CARDIOLOGY, MATERIALS Researchers at Harvard University have created a fish-like construct from human stem cell-derived cardiac muscle. The structure can beat and swim autonomously, and is inspired by zebrafish. So far, the researchers have shown that the fish can survive and swim for over 100 days, and they hope these new structures...

Stem cell infusion boosts sepsis survival in mice
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Stem cell infusion boosts sepsis survival in mice

by eLife Credit: Pixabay/CC0 Public Domain A one-time infusion of stem cells from bone marrow improves the survival of mice with sepsis, shows a study published today in eLife. The findings could lead to potential new treatments for sepsis, a life-threatening inflammatory condition triggered by bacterial or viral infections. Sepsis causes an overwhelming immune response that...

Beset in mucus, coronavirus particles likely travel farther than once thought
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Beset in mucus, coronavirus particles likely travel farther than once thought

by Pacific Northwest National Laboratory The mucus that covers respiratory droplets allows viral particles to remain infectious farther than previously thought, according to a modeling study published in February. Credit: Timothy Holland | Pacific Northwest National Laboratory A modeling study raises questions about how far respiratory droplets, like those that transmit the virus that causes...