by Karen Schmidt, American Heart Association Credit: Pixabay/CC0 Public Domain Women who develop a type of high blood pressure during pregnancy show signs of damage to the small blood vessels in the eye by middle age, according to new research. The findings suggest small vessel, or microvascular, disease may account for their increased risk of...
by Miguel Sena-Esteves, The Conversation Credit: Pixabay/CC0 Public Domain Two babies have received the first-ever gene therapy for Tay-Sachs disease after over 14 years of development. Tay-Sachs is a severe neurological disease caused by a deficiency in an enzyme called HexA. This enzyme breaks down a fatlike substance that normally exists in very small, harmless amounts in the brain. Without...
by Katrina Jurva, Aalto University Graphical abstract. Credit: DOI: 10.1016/j.brs.2022.01.016 Medical practitioners have used transcranial magnetic brain stimulation (TMS) for years to treat brain disorders like chronic pain and depression, yet much of the treatment’s success has relied on the hands operating the manual device. To bring a better quality of life to more patients,...
by The Francis Crick Institute Gamma Delta T cells taken from the gut. Credit: Robin Dart, Experimental Histopathology, Francis Crick Institute Researchers at the Francis Crick Institute and King’s College London have identified how specialist immune cells, called gamma delta T cells (γδ T cells), sense the body’s status quo, enabling them to assess the...
by University of Oslo When researcher Kaitlyn Tsuruda asked women whether they had heard of overdiagnosis, half said yes. But only a few in fact ticked the right answers to the in-depth follow-up questions. Credit: Cecilie Bakken Høstmark, UiO Women know less about the so-called overdiagnosis of breast cancer compared to other aspects of mammogram...
by Karolinska Institutet Fig. 1: Obesity is associated with altered phosphocreatine/creatine metabolism in human WAT. a, Polar metabolites in subcutaneous WAT of obese (n = 13) and non-obese (NO, n = 13) subjects (cohort 1) highlighting metabolites in the phosphocreatine/creatine pathway (green dots). Data are represented in a volcano plot with fold changes (log2) and adjusted P values (negative...
by Karolinska Institutet Schematic diagram of three interconnected cells forming a network. The calcium concentration and membrane potential are modelled separately in each cell. Credit: Erik Smedler The study, led by Professor Per Uhlén, presents a model and mechanism for how the risk gene CACNA1C can affect brain function and the risk of psychiatric illness....
by University of Eastern Finland Graphical abstract. Credit: https://www.mdpi.com/2073-4409/11/4/676 Researchers at the University of Eastern Finland have developed and characterized a new cell model for Alzheimer’s disease that has wide utility for research and could prove useful in early diagnosis and testing of new therapies. In collaboration with clinicians at Kuopio University Hospital, the researchers collected...
CARLY CASSELLA 10 FEBRUARY 2022 Two patients with long COVID in California have almost completely alleviated their symptoms by taking daily antihistamines, according to a newly published case report. While the evidence is anecdotal, the remarkable results aren’t without precedent, and the authors hope the stories they have detailed can give patients hope and point...
by Marcela Quintanilla Dieck, Massachusetts General Hospital Credit: CC0 Public Domain How brain cells communicate with one another remains largely cloaked in mystery, but a probe that records signals from neurons with unprecedented clarity and precision may help unlock those secrets, according to a study by researchers at Massachusetts General Hospital (MGH) and colleagues at...
