Scientists at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH) have identified a promising drug candidate for the treatment of multi-inflammatory syndrome in children (MIS-C), they report in Clinical Care Explorations. MIS-C is a rare but severe and potentially life-threatening condition that usually develops in children weeks to months after they have experienced a mild...
Month: <span>February 2022</span>
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Scientists discover mechanism behind how certain osmolytes cause kidney damage
TOKYO METROPOLITAN UNIVERSITY IMAGE: HYPEROSMOTIC STRESS LEADS TO A REORGANIZATION OF ACTIN STRUCTURE IN TUBULAR EPITHELIAL CELLS, WITH ELEVATED INCORPORATION OF ALPHA-SMA AND REORGANIZATION OF FOCAL ADHESIONS. THIS LEADS TO EMT, AS EVIDENCED BY A DECREASE IN E-CADHERIN EXPRESSION. (BOTTOM) FLUORESCENCE SIGNAL SHOWING THE DECREASE IN E-CADHERIN (LEFT) AND INCREASE IN ALPHA-SMA (RIGHT) IN KIDNEY...
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Macrophages grown for long periods in the lab can function normally when transferred back into the body
by Dresden University of Technology Alveolar macrophages are the immune cells that specifically live in the lung air sacs, here visible as red dots in an otherwise transparent mouse lung. Credit: Sara Gholamhosseinian Najjar and Michaela Burkon Macrophages are immune cells crucial for immune response, tissue repair, and the removal of cancer cells. Scientists see...
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Scientists target protein to lower risk of prostate cancer spread
by Cedars-Sinai Medical Center Prostate cancer cells. Credit: NIH Image Gallery Targeting a specific protein that is often overexpressed in prostate cancer can help prevent or delay the disease from spreading to other parts of the body, according to a study led by Cedars-Sinai Cancer investigators. The research, published in the peer-reviewed journal Nature Communications, opens the possibility of using...
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Researchers uncover new subsets of CD4+ ‘helper’ T cells
by La Jolla Institute for Immunology Credit: CC0 Public Domain T cells play important roles in helping to fight infections and cancers—and they can also drive autoimmune diseases. Now researchers at La Jolla Institute for Immunology (LJI) have discovered new genes in CD4+ “helper” T cell subset that are linked to risk of autoimmune diseases....
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Orally Dissolving Buprenorphine Tied to Severe Tooth Decay, FDA Warns
January 13, 2022 Orally dissolving medications containing buprenorphine are linked to severe dental problems, including total tooth loss, the US Food and Drug Administration (FDA) warns in a safety communication. The oral side effects of these medications, which are used to treat opioid use disorder (OUD) and pain, include cavities/tooth decay, including rampant caries; dental abscesses/infection; tooth erosion; fillings...
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How can diabetes affect the feet?
Diabetes, especially poorly controlled diabetes, can cause nerve damage and poor circulation. This can lead to foot ulcers, blisters, pain, and foot infections. In some cases, the damage can be severe. Infections in the feet can spread, damaging other organs and even becoming life threatening. Severe foot infections may mean a doctor has to amputate...
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Is there a link between red dye 40 and ADHD?
Red dye 40 is a commonly used synthetic color additive. Some research has linked food dyes to allergies and neurobehavioral effects in children, including symptoms of attention deficit hyperactivity disorder (ADHD). Researchers have extensively looked at the connection between diet and ADHD. Although data suggest that food dyes increase ADHD symptoms, they only seem to...
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Orally Dissolving Buprenorphine Tied to Severe Tooth Decay, FDA Warns
January 13 Orally dissolving medications containing buprenorphine are linked to severe dental problems, including total tooth loss, the US Food and Drug Administration (FDA) warns in a safety communication. The oral side effects of these medications, which are used to treat opioid use disorder (OUD) and pain, include cavities/tooth decay, including rampant caries; dental abscesses/infection; tooth erosion; fillings falling...
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Brain neurons identified in pre-sleep routine
FEBRUARY 22, 2022 by University of Michigan Credit: CC0 Public Domain When we are stressed or excited, it can be difficult for us to fall asleep—and finding ways to wind down prior to sleep is a habit of many. For people suffering from chronic difficulties initiating and maintaining sleep, adopting a regular behavioral pre-sleep routine was...