by NYU Langone Health Image highlights the dorsal precentral gyrus (in red), crossing the folded front surface at the top of the brain. Credit: NYU Grossman School of Medicine A region crossing the folded surface of the top of the brain, called the dorsal precentral gyrus, plays an essential role in how people use the...
by Eric W. Dolan January 30, 2022 in Mental Health New research published in Human Brain Mapping provides evidence of a shared neural mechanism that underlies sleep disturbance and mental disorders in preadolescents. The findings indicate that sleep disturbance and mental health problems are both related to the connectivity between and within two important brain networks. “I...
by Public Library of Science Credit: Unsplash/CC0 Public Domain Sleep apnea in pregnancy may increase the risk for brain and behavioral changes associated with autism, especially in males, according to a study in rats by Amanda Vanderplow, Michael Cahill, and colleagues at the University of Wisconsin-Madison, and publishing February 3rd in the open-access journal PLOS Biology....
by Cancer Research UK Credit: Unsplash/CC0 Public Domain A new study has shown that giving aromatase inhibitors instead of tamoxifen to premenopausal women with estrogen receptor positive (hormone-sensitive) breast cancer significantly reduces the risk of breast cancer recurrence. The results have been published today in The Lancet Oncology. For women with hormone-sensitive, operable breast cancer, giving...
by Anne Doerr, Yale University Credit: Yale University A new study by researchers at Yale Cancer Center shows inhibition of the CECR2 gene prevents triple-negative breast cancer from advancing or metastasizing. The discovery is an early step in finding new therapeutics for triple-negative breast cancer (TNBC), one of the most difficult disease sub-types to treat....
by Cell Press The hallmarks of adipose tissue dysfunction. Credit: Sakers et al./Cell Obesity is known to cause cardiometabolic diseases like hypertension and diabetes but attributing these diseases to merely an overabundance of fat is a simplification. On a basic level, fat acts as a receptacle to store energy, but upon a closer look it...
by University of Bristol Credit: Pixabay/CC0 Public Domain A new study has shown how SARS-CoV-2 may contribute to severe microvascular damage seen in severely-ill COVID-19 patients by transforming human heart vascular cells into inflammatory cells, without infecting them. The University of Bristol-led research, published in Clinical Science, indicates blocking antibodies could represent a new treatment to...
by The Wistar Institute The Wistar Institute’s Dr. Dan Kulp. Credit: The Wistar Institute Nearly four decades after its discovery, HIV has killed 36.3 million people, with no vaccine in sight. However, a new study by researchers at The Wistar Institute, an international biomedical research leader in cancer, immunology, infectious disease, and vaccine development, takes...
by National Institutes of Health Workflow for prospective identification of anti-tumor, neoantigen-specific TCRs using NeoTCR signature. Based on single cell gene signature scoring of TIL clusters, we first identify candidate NeoTCR4 and NeoTCR8 cluster populations. Dominant and subdominant clonotypes within the the two candidate NeoTCR clusters are reconstructed and tested against autologous patient tumor mutations,...
by King’s College London Graphical abstract. Credit: DOI: 10.1016/j.jconrel.2021.12.005 In a new study researchers from the School of Biomedical Engineering & Imaging Sciences, in collaboration with the Noninvasive Surgery & Biopsy Laboratory led by Dr. James Choi at Imperial College London, have found that applying rapid short pulses (RaSP) of ultrasound can non-invasively deliver liposomes...
