by Menzies School of Health Research Squamous epithelial cell biofilms observed in bronchoalveolar lavage from children with protracted bacterial bronchitis or bronchiectasis. Representative maximum intensity projections of bronchoalveolar lavage stained with BacLight (A–B), fluorescent in situ hybridisation (FISH) probes (C–D), or haematoxylin and eosin (E–F). In BacLight images, DNA within intact (live) bacteria is stained...
Olfactory processing in three distinct neural waves
by Will Doss, Northwestern University Fig 1. Electrode contact locations and experimental design. (A) The location of the piriform cortex electrode contact (red dot) is shown on each participant’s (P1–P7) brain image. L, left hemisphere. (B) Schematic illustration of the olfactory task, showing odor and no-odor conditions drawn on an illustrative breathing signal (black line)....
Age-related cognitive decline linked with buildup of iron in the brain
By Rich Haridy February 01, 2022 New research homes in on a mechanism that could explain how brain iron levels increase with age Researchers at Northwestern Medicine have uncovered a mechanism they say contributes to the age-related accumulation of iron in the brain, a process some argue is a cause of cognitive decline. The study...
Cause of inflammatory bowel disease discovered
by Technical University Munich Dr. Monica Yabal, research group leader at the Institute of Molecular Immunology (front), and her team have discovered how inflammatory bowel disease leads to a chain reaction that upsets the gut microbiome. Credit: Astrid Eckert / TUM Chronic inflammatory bowel disease (IBD) is becoming increasingly widespread. Until now, however, the underlying...
An insulin-loaded patch that sticks inside a person’s cheek
by American Chemical Society A prototype patch comfortably sticks inside the cheek to deliver insulin. Credit: Adapted from DOI: 10.1021/acsabm.1c01161 Managing blood sugar levels requires round-the-clock attention for people diagnosed with diabetes. A more healthful diet and increased physical activity can help, but many with the condition also need to take regular shots of insulin—the...
The biology of how muscles change with age
by Roger Fielding, The Conversation Muscles move your limbs and body by contracting or releasing. Credit: J. Gordon Betts, Kelly A. Young, James A. Wise, Eddie Johnson, Brandon Poe, Dean H. Kruse, Oksana Korol, Jody E. Johnson, Mark Womble, Peter DeSaix via OpenStax, CC BY There is perhaps no better way to see the absolute pinnacle of...
Social isolation and loneliness increase heart disease risk in senior women
by University of California – San Diego As social networks shrink, older adults are more at risk for social isolation and loneliness. Credit: Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego During the current pandemic, social distancing has been one tool used to reduce the spread of...
Team develops new mouse model to shed light on the mystery surrounding Huntington’s disease onset
by University of California, Los Angeles The upper portion of the schematic illustrates generation of a novel mouse model of Huntington’s disease with long, uninterrupted CAG repeats. In the new model, the striatum shows RNA and protein toxicities originated from the pure CAG repeats, which lead to neuronal damage. Credit: UCLA Health/Yang Lab Researchers at...
Genome study finds unexpected variation in a fundamental RNA gene
by Johns Hopkins University School of Medicine Unexpected heterogeneity of ribosomal RNA genes in human populations revealed by genome studies suggests potential variation in protein translation by the ribosomes. Credit: Wenjun Fan, Ph.D. A genome study undertaken by Johns Hopkins Kimmel Cancer Center researchers to look for variants in a gene considered a fundamental building...
TO KEEP PROBATIONERS OUT OF PRISON, SCREEN FOR PTSD
“For the probationers that experienced serious mental illnesses, over two-thirds of them had experienced a significant number of traumatic events,” says Ashley Givens, an assistant professor in the University of Missouri School of Social Work, who interviewed 207 probationers with current mental illnesses about their trauma and analyzed how it was affecting them. In their study,...