by University of Maine Credit: CC0 Public Domain Using B vitamins to lower homocysteine levels is an effective means of reducing blood pressure and may be especially useful in the management of drug-resistant hypertension, according to researchers at the University of Maine and University of Arkansas. UMaine emeritus professor of psychology Merrill Elias, who also...
Drug that targets macrophages offers new hope to select patients with ALS
by Suzanne Leigh, University of California, San Francisco NP001 targets macrophages, a type of immune cell implicated in the destruction of neurons. Credit: Michael S. McGrath, MD, PhD A new drug has been found to slow or temporarily stall the progression of ALS (amyotrophic lateral sclerosis) in a select group of patients. The drug, a...
Neural stem cell therapy may improve metastatic cancer survival
by Melissa Rohman, Northwestern University Representative immunostainings of brain sections harvested from mice treated with LM008 anti-HER2 neural stem cells (NSCs). The amount of anti-HER2 antibodies released by NSCs (green) was measured with antihuman IgGs (yellow). Presence of HER2 antibodies binding to the membrane of HER2-positive BT474-Br cells (red). Nuclear staining (DAPI) is shown in...
‘Physiology Fights Back’ When People Are Trying to Lose Weight
Marlene Busko January 27, 2022 Metabolic adaptation — slowing of metabolism in response to weight loss — increases the length of time needed to achieve a target lower weight, a new study of premenopausal women with overweight reports. All of the 65 sedentary young and middle-aged women with overweight who were on a low-calorie diet...
New study supports pricing long-acting injectable cabotegravir to compete with generic oral HIV pre-exposure prophylaxis
MASSACHUSETTS GENERAL HOSPITAL BOSTON – The value of a new, highly effective long-acting injectable HIV prevention medication, recently approved by the Food and Drug Administration, will hinge on how it is priced, according to a study led by researchers at Massachusetts General Hospital (MGH) published in Annals of Internal Medicine. The study authors demonstrate that the superiority of long-acting...
Treatment keeps alcoholic monkeys from drinking as much
CELL PRESS A hormone produced by the liver called fibroblast growth factor 21 (FGF21) suppresses alcohol consumption in primates, finds a study published February 1 in the journal Cell Metabolism. Vervet monkeys with a strong preference for ethanol that were given an FGF21 analogue consumed 50% less alcohol. The study also studied the brain circuits involved...
Scripps Research scientists unveil promising new approach to diabetes prevention
SCRIPPS RESEARCH INSTITUTE IMAGE: A SCRIPPS RESEARCH TEAM FOUND A COMPOUND THAT PROTECTS AGAINST DIABETES-LIKE METABOLIC CHANGES IN OBESE MICE, INCLUDING THE REDUCTION IN LIVER FAT DEPOSITS OF TREATED OBESE MICE (RIGHT) COMPARED TO UNTREATED (LEFT). CREDIT: SCRIPPS RESEARCH LA JOLLA, CA—A team of scientists from Scripps Research has conducted promising early tests of a...
Study: 30-second single-leg stand better identifies post-concussive impairments in children and teens
by David J. Hill, University at Buffalo Ghazala Saleem, left, director of the Brain Function and Recovery Lab at the University at Buffalo, examines how brain injuries can affect balance, posture control and more. Credit: Douglas Levere / University at Buffalo A simple balance and gait assessment many therapists and athletic trainers use to detect...
Excess body fat tied to lower cognitive scores in adults
(HealthDay)—Both generalized and visceral adiposity are associated with lower cognitive scores throughout midlife, according to a study published online Feb. 1 in JAMA Network Open. Sonia S. Anand, M.D., Ph.D., from McMaster University in Hamilton, Canada, and colleagues used data from 9,189 participants (between 30 and 75 years of age) from the Canadian Alliance for Healthy...
Exercise harder if you want to ward off pain due to ageing
by University of Portsmouth Credit: CC0 Public Domain Those hoping to avoid one of the worst side effects of aging—bone, joint and muscle pain that doesn’t go away—might need to exercise a lot harder and more often than previously believed. According to a new study, only high levels of activity at least once a week—playing...