by University of Leeds Credit: CC0 Public Domain For more than 30 years, scientists have been trying to unravel the mystery of how a key biological molecule self assembles into a rogue protein-like substance known as amyloid, which is thought to play a role in the development of type 2 diabetes—a disease that affects 300...
by Mike Silver, Tufts University Illustration of a lipid nanoparticle surrounded by plasma proteins. Credit: Min Qiu Tufts researchers are building a reputation for precision targeting in drug delivery. Their tools: tiny lipid-based nanoparticles (LNPs) fine-tuned to latch on to specific tissues, organs, even cell types within the body. Their latest creation: LNPs that carry...
by University of York Fig. 1: Schematic model of BKPyV hit-and-run carcinogenesis hypothesis. Immune-insufficiency leads to reactivation of latent BKPyV, sloughing of actively-infected renal “decoy” cells and BKPyV viruria. BKPyV infects the G0-arrested urothelium but remains episomal. In infected urothelial cells, BKPyV LT-Ag inhibits host retinoblastoma (pRb) and disables p53, releasing urothelial cells from G0...
by The Scripps Research Institute A team at Scripps Research reveals details into how Parkinson’s disease and Lewy body dementia spread in the brain. In neurons, the LC3 protein (green) and LAMP1 protein (red) fuse together into autolysomes (yellow) where autophagy, a cellular mechanism for clearing misfolded proteins, occurs. The prominence of green shows that...
by Elsa Hahne, Louisiana State University C. elegans, commonly known as roundworms, treated with Artemisia scoparia lived up to 40 percent longer and grew visibly fatter and stockier. Credit: Bhaswati Ghosh, LSU A research team in the Louisiana State University Department of Biological Sciences led by Assistant Professor Adam Bohnert has published a landmark study...
by University College London An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia A pioneering new study led by UCL and National Institutes of Health (NIH) scientists has revealed, for the first time, why...
by Hackensack Meridian Health Credit: CC0 Public Domain A key transcription factor in T-cell immunology is crucial to the immune system’s “memory” in recognizing threats it has already faced before—and it may be possible to improve this immunological memory in vaccines, according to a new paper by scientists at the Hackensack Meridian Center for Discovery...
By Michael Irving February 22, 2022 Scientists have found a new way to fight antibiotic-resistant bacteria by preventing resistance developing in the first place Depositphotos Antibiotic-resistant bacteria are poised to become one of the most pressing health problems in coming decades, with these superbugs predicted to claim up to 10 million lives a year by 2050. Researchers...
By Ben Coxworth February 22, 2022 A test subject wears both the device and traditional sensors while sleeping at the Kempenhaeghe Epilepsy and Sleep CenterKempenhaeghe The assessment of sleep apnea typically involves spending a night at a clinic, wired up to various sensors that may actually keep the patient from sleeping normally. According to recent...
Scientific Reports volume 12, Article number: 2058 (2022) Abstract Hip fractures are a major cause of morbidity and mortality in the elderly, and incur high health and social care costs. Given projected population ageing, the number of incident hip fractures is predicted to increase globally. As fracture classification strongly determines the chosen surgical treatment, differences...
