The incidence of tuberculosis (TB) in the United States increased 9.4 percent during 2021, according to research published in the March 25 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report. Noting that the steadily decreasing incidence of TB during 1993 to 2019 slowed in the later years, followed by...
Artificial intelligence and robotics uncover hidden signatures of Parkinson’s disease
by New York Stem Cell Foundation Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia A study published today in Nature Communications unveils a new platform for discovering cellular signatures of disease that integrates robotic systems for studying patient cells with artificial intelligence methods for image...
New study reveals why HIV remains in human tissue even after antiretroviral therapy
by Tarwinder Rai, University of Alberta P2X1 is strongly expressed on CD73+CD8+ T cells and its inhibition partially restores the potential effects of ATP. (A) Representative histogram plots, and (B) cumulative data showing P2X1 expression in CD73-/CD73+ CD8+ T cells. (C) Representative histogram plots, and (D) cumulative data of CD73 expression with/without treatment with ATP (25 μM) and...
The dangers of eating raw meat
by Colin Michie, The Conversation Credit: RossHelen/Shutterstock Rising energy and gas prices might make you think twice about firing up your stove for a roast or stew. Why cook that meat? After all, your menu could include trendy beef carpaccio, flavorsome wild boar’s liver, coppa or pancetta. If you learned to like raw meat, you...
Caught COVID? Here’s what you should and shouldn’t do when self-isolation isn’t mandatory
by Simon Kolstoe, The Conversation Credit: ilze kalve/Shutterstock We are all tired of COVID. But even though the news has moved on to other concerning geopolitical issues, it is a fact that COVID is still very much with us. Vaccines have certainly helped drive down its worst effects, but the disease is here to stay, and...
SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids
by Max Planck Society Cross-section through part of a retinal organoid: On day 143 of their differentiation, the inner nuclear layer (bottom) contains the cell bodies of functionally distinct cells: those of the amacrine and horizontal cells (white) and Müller glial cells (red). The outer nuclear layer (top) contains the cell bodies of the photoreceptors...
Brain stimulation shows beneficial effects for motor deficits following stroke
by Max Planck Society While the patients interacted with the virtual objects, their brains were stimulated via electrodes on the scalp. Credit: MPI CBS Persistent paralysis and coordination problems are among the most common consequences of a stroke. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, the University Medical...
Study unveils new clonal relations in the mouse brain
by Ingrid Fadelli, Medical Xpress Cover art that illustrates “next-generation clonal tracing”: genetic barcodes and high-throughput sequencing can be used to reveal how “simple” cells (spheres in the ground) develop into a range of ”complex” cell types (leafs in the tree) of the brain. Image credit: Lesya Adamchuk (Ella Maru Studio, Inc.). Copyright © 2022...
Long COVID study indicates “something concerning is happening”
By Rich Haridy March 20, 2022 The research affirms objective and measurable cognitive differences can be found between long COVID patients and those with no history of infection Depositphotos Two new studies are reporting on an ongoing long COVID research project investigating the persistent effects of COVID-19 on cognition in the months after acute disease....
FDA Approves Donepezil Patches to Treat Alzheimer’s-Related Dementia
Written by Joshua Murdock, PharmD | Reviewed by Alyssa Billingsley, PharmD Published on March 17, 2022 Key takeaways: In March 2022, the FDA approved Adlarity (donepezil transdermal system) to treat Alzheimer’s-related dementia. Adlarity is a once-weekly patch that’s applied to your skin. Patches are often helpful if you can’t swallow pills or if pills cause...