by University of California – San Diego EV isolation workflows using either Verita™ or ultracentrifugation methods. Credit: Communications Medicine (2022). DOI: 10.1038/s43856-022-00088-6 A novel screening platform has flagged more than 95% of stage 1 cancers, according to a pilot study published in Nature Communications Medicine. If validated by future studies, the approach offers a new way to detect...
Researchers identify key regulatory mechanism in inflammation
by Kathy Keatley Garvey, UC Davis A control burn at the University of California, Davis. Credit: Kathy Keatley Garvey Every year some 10,000 burn victims in the United States undergo an acute inflammatory reaction and die of burn-related infections, according to the Centers for Disease Control and Prevention. Now a newly published study by a...
Team develops new process for evaluating impacts of gene edits that alter rather than ‘knock out’ DNA code
by ChristianaCare Gene Editing Institute CRISPR-associated protein Cas9 (white) from Staphylococcus aureus based on Protein Database ID 5AXW. Credit: Thomas Splettstoesser (Wikipedia, CC BY-SA 4.0) A new study from scientists at ChristianaCare’s Gene Editing Institute is advancing the safety and efficacy of using CRISPR gene editing in patient treatments by demonstrating how to identify and...
Potential new COVID-19 immunotherapy could protect the vulnerable
by QIMR Berghofer Medical Research Institute Fig 1. Schematic representation of donor selection and generation of SARS-CoV-2-specific T cells for T-cell therapy. Donors for T-cell expansion were selected from a cohort of 60 SARS-CoV-2-convalescent individuals whose cells had been screened for reactivity to SARS-CoV-2 antigens using an intracellular cytokine assay. Venn diagrams represent the number...
Researchers use AI to predict antidepressant outcomes in youth
by Colette Gallagher, Mayo Clinic Figure 1. (A) Envisioned use of proposed probabilistic graph-based tool to derive prognoses of treatment outcomes in children and adolescents treated with fluoxetine or duloxetine. (B) Trajectories of Children’s Depression Rating Scale-Revised (CDRS-R) total score in patients treated with fluoxetine. (C) The machine learning workflow. Credit: Journal of Child Psychology and...
Prescribing for anxiety has increased in those under age 35
by University of Bristol Credit: Pixabay/CC0 Public Domain Researchers from the University of Bristol have found that there have been increases in incident prescribing of most anti-anxiety medications (called anxiolytics) in recent years, which have been substantial in young adults (aged under 25). This may reflect better detection of anxiety, increasing severity of symptoms, increasing...
Vitamin B3, niacinamide and reducing skin cancer risk: What does the research say?
by Deshan Sebaratnam, The Conversation Anything that can help minimise the burden of skin cancer is worth considering. Credit: Shutterstock If you’ve had a skin cancer check lately, you might have been told to consider adding a daily vitamin B3 pill to your skin safety regime (hopefully, you already use sunscreen, wear sun-smart clothes and...
Research dispels myth that COVID-19 vaccines cause infertility, but misinformation persists
by Julian Daniel Sunday Willett, The Conversation COVID-19 vaccines do not increase the risk of miscarriage. Credit: Shutterstock Misinformation about COVID-19 vaccines and fertility has propagated online despite the vaccines’ clear safety profile. Fortunately, those considering having kids can relax when it comes to these crucial shots. These claims lack any realistic basis. As a medical doctor and...
Abortion pills are just as safe to prescribe based on a patient’s medical history as after an in-person exam
by Ushma Upadhyay, The Conversation Credit: Unsplash/CC0 Public Domain For many people, accessing abortion care can be a major challenge. Abortion services are usually only available in certain clinics with specialized equipment like ultrasounds, often requiring long-distance travel to get there. When medication abortion, or abortion with pills, was introduced to the U.S. in 2000,...
A psychedelic drug, combined with intense therapy, improves PTSD symptoms
by American Chemical Society Credit: CC0 Public Domain Post-traumatic stress disorder (PTSD) affects millions of people each year, mostly survivors and witnesses of terrifying or shocking events, such as warfare, assaults or disasters. Because existing treatments don’t work for everyone, new therapies are urgently needed. Today, scientists report results and follow-up data from a phase...