by Elizabeth Chapin, University of Kentucky Space-filling model of the Cholesterol molecule. Credit: RedAndr/Wikipedia Replenishing the body’s high-density lipoprotein (HDL) could be an effective treatment for sepsis, according to a new University of Kentucky College of Medicine study published in Science Signaling. The lab study, led by Xiangan Li, Ph.D., a professor in the Department of Physiology and the Saha Cardiovascular...
Piezo1 possible key to supporting muscle regeneration in Duchenne Muscular Dystrophy
by Perelman School of Medicine at the University of Pennsylvania Histopathology of gastrocnemius muscle from patient who died of pseudohypertrophic muscular dystrophy, Duchenne type. Cross section of muscle shows extensive replacement of muscle fibers by adipose cells. Credit: Public Domain One protein, Piezo1, is key to marshalling muscle stem cells’ unique shapes and response to...
Factors linked to excess disability identified in rheumatoid arthritis
(HealthDay)—For patients with rheumatoid arthritis (RA), higher pain, fatigue, and depressive symptoms are associated with increased odds of being in the high disability trajectory, despite similar levels of inflammation, according to a study published online March 11 in Rheumatology. James M. Gwinnutt, Ph.D., from the University of Manchester in the United Kingdom, and colleagues used data...
‘Zapping’ air passages may bring relief for severe asthma
Inhalers, pills or injections help most people control their asthma, but some with severe disease opt for cutting-edge surgery that “remodels” their airways to improve their breathing. Bronchial thermoplasty shrinks smooth muscle in the lungs, which prevents them from tightening up and causing an attack. The U.S. Food and Drug Administration approved the treatment for adults with severe asthma in...
Game-changing new therapy to lower cholesterol and stabilize plaques associated with heart attack
by Monash University Credit: JACC: Cardiovascular Imaging (2022). DOI: 10.1016/j.jcmg.2022.03.002 A novel new therapy has been found to reduce harmful plaque in arteries and change its composition so it is less likely to rupture and cause a heart attack, following a clinical trial led by the Victorian Heart Institute (VHI) at Monash University. The HUYGENS study treated...
Antabuse may help revive vision in people with progressive blinding disorders
by University of California – Berkeley A mouse retinal ganglion cell (green), which becomes hyperactive in degenerative vision disorders. Other retinal cell types are labeled in blue. Hyperactivity interferes with the proper transfer of signals from the retina to the brain. Richard Kramer’s lab at UC Berkeley has discovered what causes hyperactivity and has identified...
7 in 10 long COVID patients still battle memory and concentration problems
MARCH 18, 2022 by Study Finds CAMBRIDGE, United Kingdom — The vast majority of people dealing with “long COVID” are experiencing memory and concentration problems — months after their actual coronavirus infection, a new study warns. Researchers at the University of Cambridge say seven in 10 people experiencing the lingering effects of COVID are now struggling...
With trial success in kidney disease, Lilly, Boehringer make case for broader use of diabetes drug
Jonathan Gardner Senior Reporter Eli Lilly & Co. Dive Brief: Eli Lilly and Boehringer Ingelheim’s drug Jardiance kept clinical trial participants with kidney disease from needing dialysis or a transplant, the companies announced Wednesday, a finding that cements the diabetes pill’s potential as a treatment for a wider array of metabolic diseases. The trial was expected...
How to manage morning stiffness with rheumatoid arthritis
Many with people with rheumatoid arthritis are familiar with stiff joints in the morning. But what causes this morning stiffness, and how can people get rid of it? Rheumatoid arthritis (RA) is an autoimmune condition that attacks the joints, causing inflammation, pain, and stiffness, including morning stiffness. Morning stiffness is a widespread problem among those with RA....
Vaccine effectiveness wanes after three months among care home residents
by University College London Credit: Pixabay/CC0 Public Domain Vaccination-acquired immunity against COVID-19 wanes substantially after three months among elderly care home residents, suggesting that regular booster jabs may be needed for this group, according to preliminary findings from the Vivaldi study led by UCL researchers. The study, funded by the UK Health Security Agency and...