by University of Illinois at Chicago Figure 1. SOD1G93A mice have slow intestinal mobility, decreased rotarod test time and grip strength during ALS progression. (a) SOD1G93A mice significantly increased gut transit time starting at 2-month-old compared to WT mice. In age-matched WT and SOD1G93A mice, intestinal mobility was tested using Evans blue marker (5% Evans blue, 5% gum...
by Max Planck Society Test system for the detection of coronavirus antibodies (enzyme-linked immunosorbent assay (ELISA)). Credit: Max Planck Institute of Molecular Physiology When our immune system comes into contact with the SARS-CoV-2 coronavirus, it fights back and produces antibodies. A similar immune response is triggered by coronavirus vaccines. However, there is still little data...
by Osaka University Electrocorticogram (ECoG) recordings were taken from 17 patients with epilepsy who had implanted subdural cortical electrodes related to visual perception. A decoder was trained to estimate the semantic meaning of the images that the patients were viewing from the intracranial ECoG recording using visual-semantic space. Based on the real-time inferred semantic information...
Ewen Callaway A scan using functional magnetic resonance imaging, or fMRI, shows areas of the brain active during speech. Credit: Zephyr/Science Photo Library In 2019, neuroscientist Scott Marek was asked to contribute a paper to a journal that focuses on child development. Previous studies had shown that differences in brain function between children were linked with performance...
Reviewed by Emily Henderson, B.Sc. Mar 15 2022 Could a spritz of super-tiny particles of gold and peptides on a damaged heart potentially provide minimally invasive, on-the-spot repair? Cutting-edge research led by University of Ottawa Faculty of Medicine Associate Professors Dr. Emilio Alarcon and Dr. Erik Suuronen suggests a spray-on technology using customized nanoparticles of...
Reviewed by Emily Henderson, B.Sc. Mar 18 2022 An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer’s patients and in people without diagnosed dementia. The study, published in Neurobiology of disease, highlights the...
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched a Phase 1 clinical trial evaluating three experimental HIV vaccines based on a messenger RNA (mRNA) platform—a technology used in several approved COVID-19 vaccines. NIAID is sponsoring the study, called HVTN 302, and the NIAID-funded HIV Vaccine...
Scientists at the Cancer Research UK Cambridge Institute used a personalised blood test for patients, which is a type of liquid biopsy that can pick up tiny fragments of DNA that are released into the blood as tumours grow. This DNA, called circulating tumour DNA (ctDNA), can reveal the state of the tumour, its location and potentially...
TOHO UNIVERSITY IMAGE: ON THE 2-MINUTE WALK TEST, AN INCREASED WALKING DISTANCE WAS OBSERVED IN 10 OUT OF 11 PATIENTS. THE MEAN WALKING DISTANCE ALSO IMPROVED AFTER HAL-BASED TRAINING. CREDIT: OSAMU KANO Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that presents with various symptoms, such as muscle weakness, dysphagia, dysarthria, and respiratory...
SCIENCE CHINA PRESS IMAGE: OVEREXPRESSION OF CLYBL COULD LEAD TO THE LOSS OF UPSTREAM METABOLITES, THUS RESULTING IN THE REDUCTION OF ITACONATE. ITACONATE CAN INHIBIT SUCCINATE DEHYDROGENASE (SDH), ACTIVATE NRF2/NFE2L2 VIA ALKYLATION OF KEAP1, AND INHIBIT CASPASE-1-MEDIATED CLEAVAGE OF IL-1Β AND IL-18 TO AVOID EXCESSIVE INFLAMMATION VIA THE BLOCKAGE OF NLRP3 INFLAMMASOME ACTIVATION. CREDIT: ©SCIENCE...
