by McGill University Graph showing relation between type of drug, descriptive words and neurotransmitter. Credit: Danilo Bzdok Psychedelics are now a rapidly growing area of neuroscience and clinical research, one that may produce much-needed new therapies for disorders such as depression and schizophrenia. Yet there is still a lot to know about how these drug...
Updated: Biogen finally publishes PhIII results for Aduhelm as critics chastise low-ranking journal, ‘gentle and unrevealing’ peer review
Zachary BrennanSenior EditorBiogen quietly announced at a conference in Spain today that a manuscript of the Phase III results for the company’s controversial Alzheimer’s drug Aduhelm has finally been published in a tiny journal with a conflicted chief editor, almost a year after the drug won its accelerated approval. The manuscript was published Wednesday in...
Surge of HIV, tuberculosis and COVID feared amid war in Ukraine
Leslie Roberts A bombed hospital in Volnovakha in Ukraine’s Donetsk region on 12 March.Credit: Anadolu Agency via Getty Adding to the brutal, immediate effects of Russia’s invasion, the Ukrainian people are facing an onslaught of infectious diseases. Some threats — such as the spread of COVID-19 — are immediate, as people huddle in basements, subway stations...
Risk Factors for Chronic Kidney Disease
By Hidaya Aliouche, B.Sc. Reviewed by Emily Henderson, B.Sc. Chronic kidney disease is defined as damage of the renal parenchyma that results in chronic deterioration of kidney function and may result in progression to end-stage renal disease. It is a non-communicable disease that includes a range of physiological disorders which are attributed to abnormal renal...
Protect against aging and age-related disease with the MondoA protein
Researchers from Osaka University show that activation of a protein called MondoA can protect against age-related diseases and cellular changes associated with aging. A step toward discovering the fountain of youth could involve protecting against the inevitable accumulation of “senescent” cells associated with aging and age-related diseases. Now, researchers from Japan have identified the Mondo A...
Bioengineers aim to build a heart, one layer at a time
Using advanced 3D printing techniques, Mark Skylar-Scott and his team want to transform a paste made of living cells into hearts and other organs. For an engineer, few human organs are more enticing than the human heart. Its chambers pump in perfect unison; its materials are pliable, yet contract on demand; its shape and motion are perfectly...
Modified Red Blood Cells for COVID-19 Vaccination
MARCH 15TH, 2022 CONN HASTINGS CARDIOLOGY, MATERIALS, MEDICINE, NANOMEDICINE Researchers at McMaster University in Ontario, Canada created engineered red blood cells to act as a new COVID-19 vaccine technology. The cell membranes have been studded with the SARS-CoV-2 spike protein, and in experiments the researchers have conducted in mice the cells can trigger an immune...
Tricking the body to treat breast cancer
SANFORD BURNHAM PREBYS IMAGE: CHARLES SPRUCK, PH.D. CREDIT: SANFORD BURNHAM PREBYS With the help of two new grants from the National Institutes of Health totaling more than $4.4 million, Sanford Burnham Prebys professor Charles Spruck, Ph.D., and his team are refining a cutting-edge breast cancer treatment. The new approach, known as viral mimicry, tricks the body...
Long term exposure to air pollution linked to heightened autoimmune disease risk
BMJ Long term exposure to air pollution is linked to a heightened risk of autoimmune disease, particularly rheumatoid arthritis, connective tissue and inflammatory bowel diseases, finds research published online in the open access journal RMD Open. Environmental air pollution from vehicle exhaust and industrial output can trigger adaptive immunity–whereby the body reacts to a specific disease-causing...
Mechanism underlying Alzheimer-like damage in the brain of patients with Down Syndrome
TEMPLE UNIVERSITY HEALTH SYSTEM (Philadelphia, PA) – Life expectancy for individuals with Down syndrome has grown in recent decades, thanks in large part to progress in patient care and treatment. But with survival into the fifth and sixth decades of life now possible, increasing numbers of these individuals are affected by conditions linked to aging,...