Month: <span>March 2022</span>

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NTU Singapore scientists develop novel “Trojan horse” drug delivery system using protein-based microdroplets
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NTU Singapore scientists develop novel “Trojan horse” drug delivery system using protein-based microdroplets

NANYANG TECHNOLOGICAL UNIVERSITY IMAGE: (FROM LEFT TO RIGHT) PROFESSOR ALI MISEREZ, FROM THE SCHOOL OF MATERIALS SCIENCE & ENGINEERING AND THE SCHOOL OF BIOLOGICAL SCIENCES, AND NTU PHD STUDENT YUE SUN FROM THE SCHOOL OF MATERIALS SCIENCE AND ENGINEERING. CREDIT: CREDIT TO NANYANG TECHNOLOGICAL UNIVERSITY Scientists from Nanyang Technological University, Singapore (NTU Singapore)have developed a novel...

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Type 1 diabetes can be predicted with epigenetic changes

UNIVERSITY OF TURKU Children who develop type 1 diabetes show epigenetic changes in the cells of their immune system already before the antibodies of the disease are detected in their blood. The findings of two new studies offer new opportunities to identify the children with the genetic risk for developing diabetes very early on. Epigenetic...

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Alzheimer’s pathology, not cognitive decline, drives neuropsychiatric symptoms

ELSEVIER Philadelphia, March 16, 2022 – Alzheimer’s disease (AD) eventually leads to severe cognitive decline, but most affected individuals also develop distressing neuropsychiatric symptoms. These earlier effects may be more subtle and are not well understood; it remains unclear whether they arise directly from AD pathology or secondarily as psychological reactions due to the cognitive deficits. Now, a...

A CNIC study highlights the risks of mitochondrial therapeutic interventions
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A CNIC study highlights the risks of mitochondrial therapeutic interventions

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) IMAGE: ANA VICTORIA LECHUGA-VIECO, RAQUEL JUSTO, JOSÉ ANTONIO ENRÍQUEZ, JESÚS VÁZQUEZ Y ENRIQUE CALVO. CREDIT: CNIC Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term. mtDNA is...

Bacterial enzyme makes new type of biodegradable polymer
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Bacterial enzyme makes new type of biodegradable polymer

AMERICAN CHEMICAL SOCIETY IMAGE: A BACTERIAL ENZYME (CRYSTAL STRUCTURE SHOWN HERE) MAKES A NEW TYPE OF BIODEGRADABLE POLYMER, ACHOLETIN, WHICH MIGHT SOMEDAY FIND USE IN DRUG DELIVERY, TISSUE ENGINEERING OR OTHER APPLICATIONS. CREDIT: ADAPTED FROM ACS CENTRAL SCIENCE 2022, DOI: 10.1021/ACSCENTSCI.1C01570 Strings of sugars called polysaccharides are the most abundant biopolymers on Earth. Because of...

‘Elite sleeper’ genes could offer protection from neurodegenerative diseases
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‘Elite sleeper’ genes could offer protection from neurodegenerative diseases

by University of California, San Francisco Credit: Unsplash/CC0 Public Domain Some people are gifted with genes that pack the benefits of slumber into an efficient time window, keeping them peppy on only four or six hours of sleep a night, according to researchers at UC San Francisco. In addition, the scientists said, these “elite sleepers”...

Senolytic drugs can boost key protective protein against certain diseases and aspects of aging
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Senolytic drugs can boost key protective protein against certain diseases and aspects of aging

by Robert Nellis, Mayo Clinic Graphical abstract. Credit: eBioMedicine (2022). DOI: 10.1016/j.ebiom.2022.103912 Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that protects older people against aspects of aging and a range of diseases. Their findings, which are published in eBioMedicine, demonstrate this in mice and human studies. Senolytics developed at Mayo Clinic...

Scientists validate a low-risk diagnostic test for coronary artery disease
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Scientists validate a low-risk diagnostic test for coronary artery disease

by University of Glasgow 3D medical animation still showing reduced blood flow in preventing the heart muscle from receiving enough oxygen. Credit: http://www.scientificanimations.com/Wikimedia Commons, CC BY-SA 4.0 Led by Charité – Universitätsmedizin Berlin, researchers from 31 European clinical institutions, including a team from the University of Glasgow, worked together as part of the DISCHARGE trial. The aim...

Low blood folate may be linked to heightened dementia and death risks in older people
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Low blood folate may be linked to heightened dementia and death risks in older people

by British Medical Journal Credit: CC0 Public Domain Low levels of folate (vitamin B9) in the blood may be linked to a heightened risk of dementia and death from any cause in older people, suggests research published online in the journal Evidence Based Mental Health. Levels should be routinely monitored and deficiencies corrected in older age, especially...

Novel CRISPR imaging technology reveals genes controlling tumor immunity
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Novel CRISPR imaging technology reveals genes controlling tumor immunity

by The Mount Sinai Hospital Credit: Pixabay/CC0 Public Domain Mount Sinai scientists have developed a new technology allowing them to link specific genes to complex tumor characteristics at a scale and resolution not previously possible. The results could lead to new approaches for targeting anti-cancer drugs. The technology, called Perturb-map, uses a novel genetic barcode...