by Kiel University Immune responses on intestinal mucosal barriers play a key role in chronic inflammatory bowel diseases. Depicted here is the interaction between T lymphocytes with human leukocyte antigen (HLA) complex and the antigen-presenting cell. Credit: Andre Franke/Renate Nikolaus, Kiel University Chronic inflammatory bowel diseases (IBDs) like Crohn’s disease and ulcerative colitis are characterized...
Study shows mRNA vaccine technology can be used for HIV vaccines
by Sarah Avery, Duke University Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110514 Using mRNA technology like that in the COVID-19 vaccines, researchers have demonstrated a successful way to deliver a potential HIV vaccine, researchers at Duke Human Vaccine Institute report. Publishing online March 15 in the journal Cell Reports, the research team describes an important advancement...
Researchers may have unlocked the blood-brain barrier
by Isabella Backman, Yale University Fig. 1: Endothelial Unc5B controls BBB integrity. a Unc5B gene deletion strategy using tamoxifen injection in adult mice. b Immunofluorescence staining with the indicated antibodies and confocal imaging of adult brain sections at P67, 30 min after i.v cadaverine injection and reproduced on n = 4 Unc5Bfl/fl and n = 5 Unc5BiECko brains. c Quantification of...
Fruit fly study uncovers functional significance of gene mutations associated with autism
by Molly Chiu, Baylor College of Medicine Credit: Pixabay/CC0 Public Domain About 1 in 44 children in the U.S. are diagnosed with autism spectrum disorder (ASD) by the age of 8, according to the 2018 Centers for Disease Control and Prevention surveillance. How a child’s DNA contributes to the development of ASD has been more of...
A potential new test for diagnosing Lyme disease
by Tufts University A blacklegged (deer) tick. Credit: Lennart Tange For scientists and clinicians alike, one of the Holy Grails for successfully treating and curing Lyme disease is developing tests that identify the disease sooner, show when people are cured of infection, and can diagnose reinfection. Now, researchers at Tufts University School of Medicine say...
Most people don’t know these possible signs of early Alzheimer’s
By Kristen Rogers, CNN Updated 4:21 PM ET, Tue March 15, 2022 An elderly person (not involved in the research) closes his shutters to keep cool during the heatwave in Clermont-Ferrand, France, on June 25, 2019. (CNN)If you’re not familiar with the term “mild cognitive impairment,” you’re not the only one. More than 80% of Americans...
Even mild or moderate COVID-19 can affect the cardiovascular system in young adults, study shows
by Luciana Constantino, FAPESP The findings show that obesity and physical inactivity increase the impact of the disease on the autonomic nervous system. Credit: Fabio Lira A study conducted at São Paulo State University (UNESP) in Brazil shows that even mild to moderate infection by SARS-CoV-2 can cause an imbalance in the cardiovascular system of...
A new brain-computer interface with a flexible backing
by University of California – San Diego Artist rendition of the flexible, conformable, transparent backing of the new brain-computer interface with penetrating microneedles developed by a team led by engineers at the University of California San Diego in the laboratory of electrical engineering professor Shadi Dayeh. Credit: University of California – San Diego Engineering researchers have...
‘Healthspan’ is increasing even for people with common chronic conditions
by Public Library of Science By 2011, older people with most health conditions were living longer and spending a smaller proportion of remaining life with disability, than their counterparts in 1991. Cognitive impairment was the only health condition where the prevalence decreased between 1991 and 2011 but where the proportion of remaining life spent with...
Mammograms may provide clues about women’s risk for cardiovascular disease
by American Heart Association Credit: Unsplash/CC0 Public Domain Routine mammograms may provide key insights for cardiovascular disease. Detection of breast arterial calcifications on breast mammograms was associated with a higher risk of cardiovascular disease in postmenopausal women, according to new research published today in Circulation: Cardiovascular Imaging, a peer-reviewed journal of the American Heart Association journal....