ELIFE Scientists have shown how accelerated biological aging measured by an epigenetic clock may increase the risk of bowel cancer, according to a report published today in eLife. The study provides evidence that biological age might play a causal role in the increased risk of certain diseases, and paves the way for interventions that could...
Month: <span>March 2022</span>
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UCI-led study links early life adversity, microglia dysfunction, to aberrant adult stress responses, mental illness
UNIVERSITY OF CALIFORNIA – IRVINE IMAGE: “EARLY LIFE ADVERSITY IS A ROBUST RISK FACTOR FOR LIFE-LONG ABERRANT RESPONSES TO STRESS, WHICH CAN CONTRIBUTE TO SEVERAL MAJOR MENTAL ILLNESSES, INCLUDING DEPRESSION, IN ADULTHOOD. OUR FINDINGS IDENTIFY AN IMPORTANT ROLE FOR ELA-INDUCED ALTERATIONS OF MICROGLIAL ACTIONS DURING A SENSITIVE BRAIN DEVELOPMENT PERIOD, RESULTING IN AUGMENTED EXCITATORY SYNAPSES...
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New method for making tissue transparent could speed the study of many diseases
SCRIPPS RESEARCH INSTITUTE IMAGE: THIS HYBRID VISUALIZATION OF A WHOLE MOUSE CHEST AFTER SARS-COV-2 INFECTION SHOWS THE VIRAL PROTEIN IN RED AND TISSUE STRUCTURES (LUNG, BLOOD VESSEL, BONE) IN BLUE. CREDIT: SCRIPPS RESEARCH LA JOLLA, CA—Scientists at Scripps Research have unveiled a new tissue-clearing method for rendering large biological samples transparent. The method makes it...
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Scientists develop synthetic antibiotics that could save millions of lives
by University of Liverpool Credit: Pixabay/CC0 Public Domain University of Liverpool scientists have taken a significant step towards unlocking the medical potential of a new class of potent antibiotic capable of killing “superbugs” including MRSA without detectable resistance. The researchers have developed simplified synthetic versions of the molecule teixobactin, used by producer bacteria to kill...
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Reversing hearing loss with regenerative therapy
by Zach Winn, Massachusetts Institute of Technology These images show cellular regeneration, in pink, in a preclinical model of sensorineural hearing loss. The control is on the left and the right has been treated. Credit: Hinton AS, Yang-Hood A, Schrader AD, Loose C, Ohlemiller KK, McLean WJ Most of us know someone affected by hearing...
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Body alarm for blood loss can be reset to stop cardiovascular collapse
By Nick Lavars March 28, 2022 Blood system and circultaion with a human heart cardiovascular icon with anatomy from a healthy body on a background with blood cells as a medical health care symbol of an inner organ as a medical health care concept. Depositphotos In the event of blood loss, the human body has...
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Implantable immunotherapy “factory” fights cancer faster, more effectively
By Michael Irving March 28, 2022 An artist’s rendering of a MASTER implant (white), which produces and releases T cells engineered to hunt down cancer Ella Maru Studio Researchers at North Carolina State University (NCSU) have developed a marshmallow-like implant that can train a patient’s immune system to fight off cancer. In tests in mice,...
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Scans show weakened connections in brains of adolescents at risk of bipolar disorder
by University of New South Wales Credit: Unsplash/CC0 Public Domain A brain imaging study of young people at high risk of developing bipolar disorder has for the first time found evidence of weakening connections between key areas of the brain in late adolescence. Up until now, medical researchers knew that bipolar disorder was associated with reduced communication...
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Enhanced cognitive behavioral therapy can radically reduce long-term depression
by Michael Addelman, University of Manchester Credit: Pixabay/CC0 Public Domain Enhanced versions of the most commonly used talking therapy for depression significantly reduces the illness beyond six months, a meta study of over 15,000 people has concluded. The assessment of data from 157 studies of cognitive behavioral therapy led by University of Manchester and University...
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Atlas of migraine cell types sheds light on new therapeutic targets
by Brigham and Women’s Hospital Graphical abstract. Credit: Neuron (2022). DOI: 10.1016/j.neuron.2022.03.003. Headaches such as migraine are among the leading causes of morbidity worldwide, but most treatments provide only partial relief. While scientists know that migraine and related headaches are caused by activity in a part of the nervous system known as the trigeminal ganglion (TG), it...