Novel lysin Abp013 has shown promising antimicrobial ability against Acinetobacter baumannii and Klebsiella pneumoniae. Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, alongside collaborators at Nanyang Technological University, have identified a novel phage lysin — Abp013 — that could be used as an alternative antimicrobial...
Month: <span>March 2022</span>
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Keep taking the tablets – ‘big data’ provides clues on how to help prevent repeat heart attacks
People who have been treated with cholesterol– or blood pressure-lowering medications before a heart attack were nearly ten times more likely to still be taking them as prescribed 12 months after their heart attack, new research shows. To try to understand factors associated with taking protective medications, a team of Sydney researchers studied medication use in...
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New, Highly Accurate Algorithm Scales Ability to Assemble Complete Genomes
An international team led by researchers at University of California San Diego’s Department of Computer Science and Engineering has shown that a new genome assembly algorithm, called the La Jolla Assembler (LJA), vastly improves large genomes reconstruction, the process by which DNA snippets are arranged into complete genomes, which is an essential aspect of genomic...
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Vaccine and Antibody Treatment Effectiveness Blunted by All Three Omicron Subvariants
Only one currently authorized antibody treatment retains its activity against all omicron subvariants, according to new research by scientists at Columbia University and the University of Hong Kong. The study also shows that the effectiveness of mRNA vaccines is reduced against all three subvariants of omicron. The findings were published in Nature(link is external and opens in...
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Waste management in the brain may shed light on dementia
A new study suggests that a contributing factor in dementia may come down to a double dose of bad waste management in the brain. A research team led by Yale, Stony Brook University, and the University of Rhode Island found that the body’s systems for flushing waste out of the brain failed to work properly...
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New Startup Makes Developing Gene Therapies Faster and Easier
Today, cell and gene therapies treat and could even cure terminal diseases like leukemia and spinal muscular atrophy, but unlocking their full potential is still a challenge for therapy developers. Both types of therapies rely on living cells comprised of hundreds of thousands of biomolecules to work in unison. And in order for therapy developers to meet...
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Nanoparticle reduces skin and lung scarring for scleroderma, mouse study finds
The findings provide promise of targeted treatment for patients with the disease. Investigators have discovered that a biodegradable nanoparticle used in medical sutures could combat a rare, sometimes-fatal autoimmune disease. Researchers found that a unique macrophage, an immune cell that removes bacteria or dead cells, plays a key role in the chronic inflammation and scarring...
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New Vascular Contrast for Clearer Blood Vessel Imaging
MARCH 7TH, 2022 CONN HASTINGS RADIOLOGY, VASCULAR SURGERY Researchers at Johns Hopkins developed a new imaging technique that allows them to view the vasculature of experimental animals in great detail. Research into a variety of conditions, from vascular disease to cancer, relies on acquiring images of the vasculature in animals, with a variety of imaging techniques available....
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How chronic pain arises
HEIDELBERG UNIVERSITY IMAGE: SECTION OF MOUSE DORSAL HORN SPINAL CORD. BLUE MARKS CELL NUCLEI, RED THE NEURONS. GREEN HIGHLIGHTS THE ACETYLATION LEVEL OF HISTONE 3, USED TO MEASURE THE ACTIVITY OF HDAC4. CREDIT: DANIELA MAUCERI One epigenetic factor as well as one organic anion transporter (OAT1), whose function in the nervous system was hitherto unknown,...
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Unusual partners aid blood vessel growth
MEDICAL COLLEGE OF GEORGIA AT AUGUSTA UNIVERSITY IMAGE: DRS. MASUKO USHIO-FUKAI (LEFT) AND TOHRU FUKAI CREDIT: MICHAEL HOLAHAN, AUGUSTA UNIVERSITY AUGUSTA, Ga. (March 8, 2022) – Insufficient oxygen to an area like the heart or legs, called hypoxia, is a cue to our bodies to make more blood vessels, and scientists have found some unusual partners are...