by Johannes Angerer, Medical University of Vienna KMT2C methyltransferase deficiency triggers metastatic dissemination of prostate cancer. a H&E stains of urinary tract obstruction by invasive PCa in a moribund Pten∆/∆Kmt2cSET∆/∆ mouse at 39 weeks p.p. at low (top) and high (bottom) magnification. Scale bars: 200 µm. T, tumor; U, urethra. b H&E-stained sections and IHC analysis of the...
Asher Mullard A small number of people infected with Epstein-Barr virus (pictured) go on to develop multiple sclerosis years later. Credit: Dr Gopal Murti/SPL In a sprawling facility in Silver Spring, Maryland, the US Department of Defense (DoD) has amassed a hoard of epidemiological treasure. Walk-in freezers each the size of a basketball court hold...
By MAX AITCHISON FOR THE MAIL ON SUNDAY A ‘glue’ that bees use to seal their hives and fight infection could hold the key to boosting the waning power of antibiotics, according to a pioneering study. ‘Bee glue’, or propolis, is a biscuity-brown, sticky substance that honey bees produce when building their hives. It is made...
Endometriosis is a common gynecological condition that affects thousands of girls and women. Catherine McQueen/Getty Images Researchers in Europe have created new guidelines for diagnosing and treating endometriosis. They have made significant updates to five key areas in managing the condition, including diagnosis, treatment, and recurrence. The new guidelines could help patients and clinicians better...
Senescent cells accumulate with age, causing tissue dysfunction throughout the body via their inflammatory secretions. One of those dysfunctions is the age-related imbalance in bone remodeling, favoring the osteoclasts that break down bone tissue at the expense of the osteoblasts that rebuild it. The result is osteoporosis, the characteristic loss of bone mass and resilience that...
EXPERIMENTAL BIOLOGY IMAGE: KAITLIN A. FREEBERG, MS CREDIT: KAITLIN A. FREEBERG, MS Philadelphia (April 2, 2022)—Despite the myriad known benefits of exercise, many middle-aged and older adults struggle to meet physical activity recommendations. New research finds potential for high-resistance inspiratory muscle strength training (IMST) to help this population transition to a healthier lifestyle. The study...
CLEVELAND CLINIC EMBARGOED UNTIL 9:30A.M. ET., Saturday, April 2nd, 2022, Cleveland: Findings from a Cleveland Clinic-led clinical trial showed that the use of an experimental drug in severely symptomatic, hypertrophic cardiomyopathy patients significantly reduced the need for invasive procedures. The trial evaluated whether the drug, mavacamten, could be used as an alternative to heart surgery...
by University of Melbourne A part of the spleen during chronic viral infection. Dendritic cells are green, killer T cells are red, B cells are blue and stromal cells are magenta. Credit: Würzburg Institute of Systems Immunology, Max-Planck Research Group. The presence of dendritic cells, so-called ‘sentinel’ immune cells, is vital to maintain and regulate...
by Tom Avril Credit: Pixabay/CC0 Public Domain When Maria Gloria Dominguez-Bello travels to the Amazon jungle and tells villagers the reason for her visit, their first response is often laughter. “Did you come all this way just to see my poop?” they ask. She did—no humor intended—and she has been doing it for more than...
Published March 29, 2022 Ned Pagliarulo Lead Editor Jeenah Moon via Getty Images Dive Brief: An experimental inflammatory disease drug acquired by Pfizer earlier this year met all of its goals in the second of two late-stage trials testing its potential in treating ulcerative colitis, a chronic bowel disease that affects millions of people in the U.S....
