People who live with alcohol use disorder may develop a range of symptoms if they stop drinking suddenly. They may also experience vitamin deficiencies, as alcohol impairs the body’s ability to absorb vitamins and nutrients. People who misuse alcohol can experience a range of symptoms if they abruptly stop drinking. These symptoms can range from...
by University of Eastern Finland Schematic illustration depicting miR-466c targeting of murine Vegfa promoter. Credit: PLOS ONE (2022). DOI: 10.1371/journal.pone.0265948 A novel angiogenic microRNA drug can be a new option for the treatment of ischemic cardiovascular disease, according to a new study published in PLOS One by researchers from the University of Eastern Finland together with international collaborators. In...
by University of Gothenburg Credit: Pixabay/CC0 Public Domain In recent years, subcortical small-vessel disease has become an increasingly common cognitive diagnosis. Researchers at University of Gothenburg have now shown that it is possible to identify patients with the disease by combining two biomarkers that are measured in spinal fluid and blood, increasing the potential for...
by Ellen Goldbaum, University at Buffalo Efficacy and adverse events by treatment and mode dose taken. Forest plot shows the rate and adjusted hazard ratios (HRs) of outcomes by strata of mode dose of pioglitazone compared with placebo, for stroke/myocardial infarction, new-onset diabetes, weight gain, heart failure and bone fracture. Lower doses of pioglitazone appear...
by Experimental Biology A probiotic was engineered to endogenously produce L-DOPA from tyrosine using recombinant 4-hydrophenylacetate 3-monooxygenase and FAD reductase genes. The L-DOPA live-biotherapeutic is pre-activated and orally administered. Tests of the new drug delivery approach reveal steady-state plasma L-DOPA levels and brain dopamine levels in pre-clinical animal models. Credit: Piyush Padhi, University of Georgia...
by University of Michigan Credit: Pixabay/CC0 Public Domain Nearly half of all older adults now die with a diagnosis of dementia listed on their medical record, up 36% from two decades ago, a new study shows. But that sharp rise may have more to do with better public awareness, more detailed medical records and Medicare...
by University of Michigan Credit: CC0 Public Domain While it’s estimated that 1 in 3 Americans will develop a substance use disorder in their lifetime, experts know little about the long-term outcomes for people with substance use disorder symptoms from adolescence through adulthood. New University of Michigan research findings on the topic are grim: The...
A group of 36 volunteers have completed the first human challenge study of COVID-19, after being given the virus and then monitored to examine what happened to them after infection. Researchers from the Imperial College of London learned a great deal about the virus during the initial study period in March 2021 and in follow-up...
by Win Reynolds, Northwestern University Credit: CC0 Public Domain Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could lead to longer-lasting treatments and new therapeutic strategies for Human Immunodeficiency Virus (HIV). The HIV epidemic has been overlooked during the COVID-19 pandemic but represents a critical and...
By Dr. Liji Thomas, MD Apr 1 2022 Reviewed by Danielle Ellis, B.Sc. Sleep is among the most essential of human needs, but one that is often neglected. Many studies have shown that sleep deprivation puts people at risk of obesity and immune dysfunction. A new study provides insights into how experimentally-induced sleeplessness affects body...
