by University of Oxford Credit: Shutterstock New reporting guidelines, jointly published in Nature Medicine and the BMJ by Oxford researchers, will ensure that early studies on using Artificial Intelligence (AI) to treat real patients will give researchers the information needed to develop AI systems safely and effectively. Artificial Intelligence in medicine has shown promising results in numerous simulation studies, but...
World’s largest islet transplant program celebrates 20 years of changing lives for people with diabetes
by Gillian Rutherford, University of Alberta James Shapiro leads the team that developed the revolutionary Edmonton Protocol for islet cell transplants, which has proven successful in improving quality of life for people with hard-to-control diabetes over the last 20 years. Credit: Richard Siemens After 20 years of perfecting their technique, the team behind the largest...
The genetic underpinnings of severe staph infections
by Rockefeller University Credit: Pixabay/CC0 Public Domain A common culprit of skin and respiratory infections, Staphylococcus aureus is highly unpredictable. Between 20 and 30 percent of people carry quiet colonies on their skin and in their nostrils, which seldom cause problems beyond the occasional rash. But in some cases these bacteria cause infections that lead...
Home testing for syphilis gains support in wake of COVID
Carrie Arnold Some at-home syphilis tests also detect multiple other infections, such as HIV and hepatitis C.Credit: Pixel-shot/Alamy Global cases of sexually transmitted infections (STIs) have been on the rise in some countries. Even the COVID-19 pandemic — which locked down life in many ways — hasn’t halted the trend. In April, the US Centers...
Immune sensor ZBP1 links interferon treatment and dangerous inflammatory cell death during COVID-19
by St. Jude Children’s Research Hospital, Medical Xpress Scientists from St. Jude Children’s Research Hospital have shown that the innate immune sensor, ZBP1, and its associated inflammatory cell death pathway, PANoptosis, are major contributors to the negative effects of interferon treatment and high interferon levels in some COVID-19 patients. For viral infections, interferon therapy is...
Possible discovery of mechanism behind mysterious COVID-19 symptoms
by Karin Söderlund Leifler, Linköping University Picture of amyloid from the SARS-CoV-2 virus’ spike protein, seen using an electron microscope. When the spike protein is mixed with the enzyme neutrophil elastase in test tubes, branched protein fibrils are created, which potentially can cause disturbed blood coagulation in patients with COVID-19. Credit: Sofie Nyström and Per...
Sting’ protein’s efforts to clean up brain cell damage may speed Parkinson’s disease progress
In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson’s disease. Specifically, the researchers found that a protein dubbed “STING” responds to clean-up signals in brain cells...
COVID booster needed for broad protection against omicron variants
by Emily Caldwell, The Ohio State University A COVID-19 booster shot will provide strong and broad antibody protection against the range of omicron sublineage variants of the SARS-CoV-2 virus in circulation, two new studies using serum from human blood samples suggest. Researchers tested neutralizing antibody levelsagainst the BA.2 and BA.3 omicron variants and deltacron, a recombinant variant created...
Vaccination after SARS-CoV-2 infection linked to a decrease in long COVID symptom
by British Medical Journal Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID Vaccination after infection with SARS-CoV-2, the virus responsible for COVID-19, is associated with a decrease in the likelihood of long COVID symptoms, finds...
New discoveries about bone breakages related to osteoporosis medicine
Medicinal treatment of osteoporosis can sometimes lead to an unusual kind of breakage in the thigh bone. Why do these fractures occur, and how can they be tracked in a national quality register? These are the questions focused on in two newly published studies in which researchers from Linköping University (LiU) have participated. The bones in your...