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Why do some people get sicker from COVID than others?
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Why do some people get sicker from COVID than others?

by Andrew Thurston, Boston University SARS-CoV-2 particles can be seen in a macrophage in the human lung tissue–engrafted model. Credit: F. Douam and D. Kenney / Harvard Medical School Electron Microscopy Facility COVID-19 vaccines have saved at least a million lives in the United States alone, but for many people, a lingering fear remains: If—or...

Virus found in pig heart used in human transplant
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Virus found in pig heart used in human transplant

by Lauran Neergaard  In this photo provided by the University of Maryland School of Medicine, David Bennett Jr., right, stands next to his father’s hospital bed in Baltimore, Md., on Jan. 12, 2022, five days after doctors transplanted a pig heart into Bennett Sr., in a last-ditch effort to save his life. Researchers trying to...

New tool more accurately uses genomic data to predict disease risk across diverse populations
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New tool more accurately uses genomic data to predict disease risk across diverse populations

by Massachusetts General Hospital Credit: CC0 Public Domain Polygenic risk scores (PRS) are promising tools for predicting disease risk, but current versions have built-in bias that can affect their accuracy in some populations and result in health disparities. However, a team of researchers from Massachusetts General Hospital (MGH), the Broad Institute of MIT and Harvard,...

‘Stressed’ cells offer clues to eliminating build-up of toxic proteins in dementia
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‘Stressed’ cells offer clues to eliminating build-up of toxic proteins in dementia

by University of Cambridge It’s often said that a little stress can be good for you. Now scientists have shown that the same may be true for cells, uncovering a newly-discovered mechanism that might help prevent the build-up of tangles of proteins commonly seen in dementia. A characteristic of diseases such as Alzheimer’s and Parkinson’s—collectively...

New eye drops can help aging people see better: An optometrist explains how Vuity treats presbyopia
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New eye drops can help aging people see better: An optometrist explains how Vuity treats presbyopia

by Robert Bittner, The Conversation Presbyopia stiffens the lens in the eye, and when a person can’t bend their lens as easily, they are unable to focus incoming light on the correct part of the retina and images appear blurry. Credit: BruceBlaus via WikimediaCommons, CC BY-SA When people get into their 40s and beyond, their close-up vision...

New method can easily identify viruses in tumors in a routine clinical genomic sequencing assay
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New method can easily identify viruses in tumors in a routine clinical genomic sequencing assay

by Elsevier Validation of virus detection by the tumor profiling assay and novel virus associations. A: Receiver operator characteristics (ROC) curve showing performance of virus detection compared to isothermal amplification method. B: Forest plot showing enrichment of HHV6 in neuroblastoma, HHV7 in esophagogastric cancer, and HPV42 in non-melanoma skin cancer. Results are shown as an...

DNA sites linked with physical differences between sexes now also linked to disease risk
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DNA sites linked with physical differences between sexes now also linked to disease risk

by Public Library of Science Lantern slide of drawings of the male and female body, with grid lines. Made by Alex Gunn & Sons, Melbourne, Victoria, circa 1940s. Credit: Museums Victoria (Public Domain, creativecommons.org/publicdomain/mark/1.0/) Some physical traits that differ between sexes are known to be linked to certain single nucleotide polymorphisms (SNPs) in chromosomes other than...

Drugs targeting cell recycling could be used to suffocate cancer cells
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Drugs targeting cell recycling could be used to suffocate cancer cells

by Institute of Cancer Research USP25 is highly expressed and enzymatically active in PDAC compared to normal pancreatic tissue, which correlated with poor patient survival. a Histological and immunohistochemical analysis of Usp25 expression in normal pancreatic and KPCY tumor tissues. Scale bar is 100 µm. b Quantification of Usp25 positive staining area (n = 6 biologically independent animals...

What to know about flesh-eating bacteria
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What to know about flesh-eating bacteria

by Dipali Pathak, Baylor College of Medicine Credit: Pixabay/CC0 Public Domain Though warmer temperatures bring excitement for more water activities, they also can bring worries about safety surrounding those activities. An infectious diseases expert at Baylor College of Medicine shares what you need to know about a rare but often feared health concern: flesh-eating bacteria....