SCRIPPS RESEARCH INSTITUTE IMAGE: A TEAM AT SCRIPPS RESEARCH INVENTED A NEW METHOD, CALLED CATCH, THAT SHOWS HOW DRUGS HIT THEIR TARGETS IN THE BODY. CELLS TARGETED BY A DRUG (PARGYLINE SHOWN IN CYAN) CAN BE IDENTIFIED BY MULTIPLE ROUNDS OF IMMUNOLABELING (RED SHOWING NEURONS; YELLOW SHOWING DOPAMINERGIC/NORADRENERGIC NEURONS; BLUE SHOWING CELL NUCLEI). CREDIT: SCRIPPS...
Scientists detail brain dynamics implicated in neurological conditions
by University of North Carolina Health Care Immunofluorescent labeling of sections from the adult brainstem. Norepinephrine-expressing Neurons in the locus coeruleus (LC, magenta) and GFP-expressing norepinephrine-expressing neurons (green) in the dorsal subcoeruleus, adjacent to the LC. Credit: Ian Shih (UNC School of Medicine) When you daydream, or ruminate on something bothersome, or ponder the past,...
Study finds children with vegetarian diet have similar growth and nutrition compared to children who eat meat
by St. Michael’s Hospital Credit: CC0 Public Domain A study of nearly 9,000 children found those who eat a vegetarian diet had similar measures of growth and nutrition compared to children who eat meat. The study, published in Pediatrics and led by researchers at St. Michael’s Hospital of Unity Health Toronto, also found that children...
Using BMI to measure your health is nonsense. Here’s why
by Nicholas Fuller, The Conversation Credit: Shutterstock We’re a society obsessed with numbers, and no more so than when managing our health. We use smartwatches to count steps and track our daily activity, creating scores for our fitness, and monitor our heart rate and sleep quality to measure our health and well-being. Doctors can be just as...
Marijuana linked to heart disease; supplement may mitigate risk, researchers report
by Krista Conger, Stanford University Medical Center People who smoke marijuana more than once a month have an increased risk of heart attack and heart disease, Stanford researchers and their colleagues have found. Credit: Dmytro Tyshchenko/Shutterstock People who use marijuana have an increased risk of heart disease and heart attack, according to a large study...
Nothing to cry about: The development of tear duct organoids
by Osaka University Fig.1. Summary of the study Ocular surface ectoderm, which is thought to be the common primordium of the lacrimal gland and cornea, is induced in zone-3 of eye-like organoids derived from human iPS cells. After further differentiation culture, we induced and isolated lacrimal gland progenitor cells by cell sorting and successfully generated...
Does autism begin in the womb?
KOBE UNIVERSITY IMAGE: A: EXPERIMENTAL SCHEMATIC. CELLS ARE ISOLATED FROM THE FETAL YOLK SAC AND AGM AND THEIR TRANSCRIPTS ARE SEQUENCED BY NEXT-GENERATION SEQUENCING. B: CELL GROUPS FROM SINGLE-CELL ANALYSIS OF AGM PROGENITOR CELLS ARE SHOWN. C: HEATMAP OF TOP 10 ENRICHED GENES IN THE THREE CELL GROUPS (6, 12, 17) IN B. D: GENE...
Breakthrough in treatment for Dupuytren’s disease
by University of Oxford Credit: Unsplash/CC0 Public Domain Researchers at the Kennedy Institute, University of Oxford, led by Professor Jagdeep Nanchahal have demonstrated the efficacy of the anti-TNF drug adalimumab for patients with early stage Dupuytren’s disease. Dupuytren’s disease is a common condition of the hand that affects about 5% of the UK population and...
Virus might be behind mystery child hepatitis cases: US agency
CDC recommends children stay up to date on their vaccinations and that parents and caregivers practice preventive actions such as hand hygiene, avoiding people who are sick, covering coughs and sneezes, and avoiding touch the eyes, nose or mouth. Nine young children from Alabama affected by a mysterious hepatitis (inflammation of the liver) all tested...
Lowering BP According to Newest Guidance Would Cut CV Events
Marlene Busko April 26, 2022 Using the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guideline target of systolic blood pressure (BP) < 120 mm Hg, 66% of adults with chronic kidney disease (CKD) would be eligible for BP lowering, according to a study from South Korea. This represents an added > 10% of patients compared with two...