by Thomas Jefferson University Credit: Pixabay/CC0 Public Domain Obesity is a known risk factor for at least 13 types of cancer, in part because it creates ever-present inflammatory state. For years, one researcher has wondered if there’s more to the story than inflammation. New research from the lab of Dr. Elda Grabocka shows a new way that...
by Weill Cornell Medical College Weill Cornell Medicine. Credit: Sharma Lab Aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson’s disease through a cellular waste-ejection process, suggests a new study led by Weill Cornell Medicine researchers. During the process, called lysosomal exocytosis, neurons eject protein waste they cannot break down and recycle....
by Karolinska Institutet Huge clumps of E. coli (red) infecting diabetic mouse bladder. Credit: Soumitra Mohanty Lower immunity and recurring infections are common in type 1 and type 2 diabetes. Researchers at Karolinska Institutet in Sweden now show that the immune systems of people with diabetes have lower levels of the antimicrobial peptide psoriasin, which compromises...
by Ludwig Cancer Research Credit: CC0 Public Domain The cells of a subset of myeloproliferative neoplasms (MPNs), slow-growing blood cancers, have frameshift mutations in their calreticulin (CALR) gene that are associated with the disease. The tail end of this gene’s mutated protein product (CALRMUT) should be an ideal neoantigen. Yet T cells directed against the CALRMUT fragment...
by National Jewish Health Credit: Pixabay/CC0 Public Domain For the first time, researchers have shown that a class of anti-fibrotic drugs slows the progression of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA). Research conducted in part at National Jewish Health showed that pirfenidone was safe and effective in these patients. The study,...
by Uppsala University The study is based on analyses of both fecal and blood samples from 8,583 participants in the Swedish CArdioPulmonary bioImage Study (SCAPIS). Credit: Petra Olsson There are strong links between bacteria living in the gut and the levels of small molecules in the blood known as metabolites. This is the finding of...
by International Society for Stem Cell Research Induced dopaminergic neurons directly reprogrammed from the skin cells of a patient with idiopathic Parkinson’s Disease. Credit: Janelle Drouin-Ouellet, University of Montreal, Canada The possibility to make virtually all cell types of the human body from induced pluripotent stem cells (iPSCs), which are embryonic-like cells generated from a...
by Weill Cornell Medical College Credit: CC0 Public Domain A common, spontaneous mutation in blood stem cells, which has been linked to higher risks of blood cancer and cardiovascular disease, may promote these diseases by altering the stem cells’ programming of gene activity and the mix of blood cells they produce, according to a study...
by Johannes Angerer, Medical University of Vienna Receptor-Binding Domain and Angiotensin-Converting Enzyme 2 Interaction Inhibition in Patients With Hematologic Malignant Neoplasm With or Without B Cell–Targeting Treatment Nominal P values without correction for multiple testing were calculated using Wilcoxon signed-rank test. Bars represent the IQR, whiskers represent the 25th/75th percentile ± 1.5x IQR, and horizontal...
by Aarhus University Graphical abstract. Credit: Cell Reports Medicine (2022). DOI: 10.1016/j.xcrm.2022.100740 For decades, researchers from all over the world have been working hard to understand Alzheimer’s disease. Now, a collaboration between the Department of Biomedicine and the Department of Clinical Medicine at Aarhus University has resulted in a flock of minipigs that could lead to a...
