by Rockefeller University Press Transmission electron micrograph of SARS-CoV-2 virus particles (colored yellow) within the endosomes of a heavily infected nasal olfactory epithelial cell. Credit: NIAID Researchers in Germany have discovered that age-dependent impairments in antiviral interferon proteins underlie the increased susceptibility of older patients to severe COVID-19. The study, published today in the Journal of...
by University of Basel High-throughput drug screen reveals estrogen receptor α (ERα) induction in triple-negative breast cancer (TNBC) upon polo-like kinase 1 (PLK1) inhibition. A Schematic of the high-throughput drug screen to identify inhibitors that induce ERα signaling in TNBC. Cells without active ERα signaling do not express GFP, whereas cells with active ERα signaling...
by Adam Zewe, Massachusetts Institute of Technology The sensor operates like a low-power radar, where it captures radio waves to assess patients’ walking patterns, their disease progression, and the effects of medications. Credit: Liu et al., Sci. Transl. Med. 14, eadc9669 (2022) Parkinson’s disease is the fastest-growing neurodegenerative disease, now affecting more than 10 million people...
by Bob Yirka, Medical Xpress The circadian rhythm and melatonin production of a human. Credit: Srruhh, CC BY-SA 4.0 , via Wikimedia Commons A team of researchers with members from Université Claude Bernard Lyon, Hospices Civils de Lyon and Paris-Saclay Université has found a link between pain sensitivity and a person’s circadian rhythm. In their paper...
A new study introduces a new neurocomputational model of the human brain that could shed light on how the brain develops complex cognitive abilities and advance neural artificial intelligence research. The study was carried out by an international group of researchers from the Institut Pasteur and Sorbonne Université in Paris, the CHU Sainte-Justine, Mila –...
BY AMY CAMPBELL, MS, RD, LDN, CDCES | SEPTEMBER 13, 2022 Eating with diabetes is often thought to be one of the hardest parts about having the condition. Not only do you need to pay attention to carbohydrates, portions, and timing, but it can seem like everything you eat affects your blood sugars. (And eating is just part...
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THE LANCET Peer-reviewed/Modelling/People A new modelling study estimates 8.4 million individuals were living with Type 1 Diabetes (T1D) globally in 2021 with an additional 3.7 million ‘missing people’ who would be alive with T1D if their mortality matched general population rates. The model predicts between 13.5 – 17.4 million people will be living with T1D...
SCRIPPS RESEARCH INSTITUTE LA JOLLA, CA— Calibr, a division of Scripps Research focused on the “bench to bedside” development of transformative medicines, today announced encouraging preliminary data from the first nine subjects in a first-in-human Phase 1 clinical trial studying the first switchable CAR-T cell product (CLBR001 + SWI019) for patients with B cell malignancies. The...
NIH/NATIONAL HEART, LUNG AND BLOOD INSTITUTE Adults who cut back on sleep for 6 weeks had increased markers of inflammation Getting a consistent good night’s sleep supports normal production and programming of hematopoietic stem cells, a building block of the body’s innate immune system, according to a small National Institutes of Health-supported study in humans...
