DUKE UNIVERSITY IMAGE: CIRCULATING ANTIBODY (WHITE) IS PREVENTED FROM ACCESSING OLFACTORY EPITHELIUM BY A PREVIOUSLY UNKNOWN BLOOD-OLFACTORY BARRIER, THE BOB. THIS NEWLY IDENTIFIED BARRIER KEEPS SOME OF THE LARGER MOLECULES OF THE BODY’S IMMUNE SYSTEM OUT OF OLFACTORY EPITHELIUM (GREEN), LEAVING A GAP IN PROTECTION MAY EXPLAIN TWO MYSTERIES OF COVID. CREDIT: ASHLEY MOSEMAN LAB,...
LA JOLLA INSTITUTE FOR IMMUNOLOGY IMAGE: LEFT TO RIGHT: LJI PROFESSOR SHANE CROTTY, PH.D., AND LJI POSTDOCTORAL FELLOW HARRY SUTTON, PH.D. CREDIT: MATT ELLENBOGEN, LJI LA JOLLA, CA—Researchers at La Jolla Institute for Immunology (LJI) have discovered how the immune system can transform into an antibody-making machine capable of neutralizing one of the most elusive...
by Public Library of Science Shown is an increased density of synapses (green) that contact motoneurons (purple) in the spinal cord of an injured animal after treatment with the small molecule TTK21-These are important for motor function. Credit: Franziska Mueller (CC-BY 4.0, creativecommons.org/licenses/by/4.0/) Currently, spinal cord injury does not have any effective treatments; physical rehabilitation can...
by Linköping University Credit: Pixabay/CC0 Public Domain Researchers at Linköping University, Sweden, have discovered a biological mechanism that increases the strength with which fear memories are stored in the brain. The study, carried out in rats, is published in Molecular Psychiatry. It provides new knowledge on the mechanisms behind anxiety-related disorders, and identifies shared mechanisms behind...
by University of Southern California Credit: Pixabay/CC0 Public Domain A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer’s disease, expanding the known gene targets for the disease and presenting a new potential avenue for treatment, according to a new USC study. The protein, called SHMOOSE,...
by University of Pittsburgh Credit: Pixabay/CC0 Public Domain Simple computer-based neurocognitive training—using positive words and pictures designed to boost self-worth—prolongs the antidepressant effects of ketamine in people with treatment-resistant depression, University of Pittsburgh researchers report today in the American Journal of Psychiatry. Results of a double-blind, randomized clinical trial conducted in Pittsburgh suggest that low-cost, automated...
by University of Birmingham Credit: CC0 Public Domain People who experience frequent bad dreams in middle age are more likely to be diagnosed with dementia later in life, according to research at the University of Birmingham. A new study, published in The Lancet journal, EClinicalMedicine, suggests nightmares may become prevalent several years or even decades before the characteristic...
by Rockefeller University Credit: Unsplash/CC0 Public Domain It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, and even death in others. A new paper published in Nature may explain the genetic underpinnings of this dichotomy. The researchers demonstrated that mice with gene variants...
by Wiley Credit: Pixabay/CC0 Public Domain New research in Acta Obstetricia et Gynecologica Scandinavica suggests that stress may affect a woman’s fecundability, or her probability of achieving a pregnancy within a menstrual cycle. The study assessed allostatic load, which refers to the cumulative “wear and tear” of chronic stress and life events, in 444 women who were...
by Wiley Chemical structure of Penicillin G. The sulfur and nitrogen of the five-membered thiazolidine ring are shown in yellow and blue respectively. The image shows that the thiazolidine ring and fused four-membered β-lactam are not in the same plane. Credit: Public Domain A new guideline published in Clinical & Experimental Allergy will help clinicians evaluate and...
