by Perelman School of Medicine at the University of Pennsylvania Multivariable Cox Proportional-Hazards Models in the TOPCAT trial. Multivariable Cox proportional-hazards models that include endotrophin, NT-proBNP, and MAGGIC (Meta-Analysis Global Group in Chronic Heart Failure) risk score as predictors of (Panel A) the primary end point, (Panel B) death or heart failure–related hospital admission, and (Panel...
by Haleigh Ehmsen, Northwestern University Response rates in all FLT3mut patients treated at any dose (n = 56) and in those who did (n = 35) or did not (n = 21) receive prior treatment with a FLT3 TKI. mCRc was defined as CR + CRi + CRp per criteria used in the ADMIRAL study. CR, complete...
by UT Southwestern Medical Center Colonoscopic image of mice lacking the Pak2 gene showing severe colon inflammation. Credit: UT Southwestern Medical center A set of interacting molecules in immune cells of the gut is responsible for preventing the inflammation seen in inflammatory bowel diseases (IBD), UT Southwestern researchers report in a new study. The findings,...
by American Heart Association Credit: Pixabay/CC0 Public Domain After a heart attack, people with an autoimmune disease were more likely to die, develop heart failure or have a second heart attack compared to people without an autoimmune disease, according to new research published today in the Journal of the American Heart Association. Autoimmune diseases, such as rheumatoid...
by Tohoku University The ex vivo bioluminescence intensity of the metastatic LN was lowest in the Single M-TBI + LDDS group, followed by the Single M-TBI group and the LDDS group, and all these groups exhibited significantly lower levels than the Non-treatment group (Fig. 1A). The ex vivo bioluminescence intensity in the lungs of the...
by Pasteur Institute Virtual reality environment seen by mice. Credit: Ruy Gómez-Ocádiz, Christoph Schmidt-Hieber, Institut Pasteur The memory system alternates between periods of learning and remembering. These two functions are controlled by different neural circuits. Using an animal model, scientists from the Institut Pasteur recently identified a neural signal in the hippocampus, a brain region...
by University of Minnesota Medical School Graphical abstract. Credit: Med (2022). DOI: 10.1016/j.medj.2022.07.008 University of Minnesota researchers and their collaborators at the National Cancer Institute (NCI) investigated the role of a new intracellular checkpoint gene in regulating T-cell function against solid tumors. Known as CISH, the team published results in Med that show the checkpoint gene plays a key...
by Marcia Kaye, University of Toronto Mississauga Human colorectal cancer cells. Credit: National Cancer Institute/Unsplash While chemotherapy drugs can be lifesaving, they don’t work for all patients or for all cancers. But a team of UTM researchers is looking at new ways to use special types of light to target cancer cells resistant to current drug...
by Brigham and Women’s Hospital Credit: CC0 Public Domain Frailty is defined as reduced physiological reserve and ability to cope with acute stresses. Up to half of adults over the age of 85 live with frailty and thus, preventative measures are greatly needed. Investigators at Brigham and Women’s Hospital, a founding member of the Mass...
by Singular Research Centers Network Co-localized version of “Isness” (“Isness-C”). Credit: David Glowacki A paper published in the journal Scientific Reports demonstrates how virtual reality group experiences can produce responses similar to those triggered by psychoactive drugs, such as hallucinogenic mushrooms or LSD. Describing the sensations that arose immediately following a left-hemisphere stroke, brain scientist...
