by Translational Genomics Research Institute Sample overview and subgroup classification. (A) Common molecular alterations and subgroup classifications of 20 MB PDX models. (B) Partial least squares discriminant analysis on differentially abundant proteins (ANOVA q < 0.05) between subgroups. Ellipses indicate 95% confidence interval. (C) Partial least squares discriminant analysis on differentially abundant phosphosites (ANOVA q...
By EKATERINA PESHEVA September 15, 2022 Image: agcuesta/iStock/Getty Images Plus Harvard Medical School scientists and colleagues at Stanford University have developed an artificial intelligence diagnostic tool that can detect diseases on chest X-rays directly from natural-language descriptions contained in accompanying clinical reports. The step is deemed a major advance in clinical AI design because most...
BY QUINN PHILLIPS | SEPTEMBER 21, 2022 The hand disorder known as trigger finger is more common in people with diabetes who have a higher A1C level (a measure of long-term blood glucose control), according to a new study published in the journal Diabetes Care. As the study authors noted, diabetes is known to increase the risk for trigger finger — a...
by New York University Credit: Pixabay/CC0 Public Domain Long-term memories rely on both the repetition of events and an intricate neurological learning process in making these memories last, shows a new study by a team of neuroscientists. Its findings provide a more detailed understanding of how these types of memories are formed as well as...
by Columbia University Labeled in red and green in this photo illustration are axons of sensory cells in a single glomerulus within a mouse brain’s olfactory bulb. Credit: Hani Shayya/Stavros Lomvardas/Columbia’s Zuckerman Institute Rendering the invisible visible is among scientists’ favorite challenges. The sea creature-like images are microscopic portraits of brain cells that make sense...
by Lori Dajose, California Institute of Technology An example of a Stroop Paradigm test. It takes a bit of extra mental effort to name the color of a word when it doesn’t match the word itself. Credit: Caltech Alzheimer’s disease is a neurodegenerative condition that damages a person’s ability to think, remember, and perform basic...
by University of California – San Diego Credit: Unsplash/CC0 Public Domain In the first known study of its type, an international team of researchers evaluated whether high research and development (R&D) costs explain high drug prices in the United States. “There is a presumption that high R&D costs justify high drug prices. If that were...
by Kelly Malcom, University of Michigan Chronic liver disease is associated with NIK upregulation in cholangiocytes. A, B Human liver sections were stained with antibodies to NIK and K19. A Representative images. Scale bar: 200 μm. B NIK+, K19+, and NIK+K19+ cells were counted and normalized to total cells. Control: n = 3 subjects, PBC: n = 3 subjects, PSC: n = 3 subjects, HBV: n = 5 subjects, HCV: n = 3 subjects, Alcohol: n = 3 subjects. C, D C57BL/6J male mice were...
by Claudia Coons, UC Davis RNA-Seq variant calling identified a psoriasis-associated SNP in 3′ UTR of the PCSK9 gene. (A) SNP calling was performed on 2 separate psoriasis RNA-Seq data sets (12, 14), and ORs were calculated using the allele counting method. Fisher’s exact test was performed to calculate P values. Names of analyzed data sets...
The number of norovirus outbreaks increased in the 2021 to 2022 surveillance year, returning to levels similar to prepandemic levels, according to research published in the Sept. 23 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report. Anita K. Kambhampati, M.P.H., from the CDC in Atlanta, and colleagues examined norovirus...
