Fibrolamellar carcinoma is a rare and lethal liver cancer that disproportionately harms young adults. It is nearly incurable. Surgery can remove the tumor, but no existing therapies are capable of reining in the cancer once it starts to spread throughout the body. The findings in Clinical Cancer Research highlight a promising drug target for an intractable disease,...
Month: <span>November 2022</span>
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Many adolescents game a lot without negative effects on their wellbeing
A new study published by University of Oxford researchers in an open-access journal, JMIR Pediatrics and Parenting, shows that although many school-age adolescents spend considerable time gaming, it does not hurt their well-being. The OxWell Student Survey is one of England’s largest school surveys of adolescent health and wellbeing. More than 12,000 secondary school-aged students (12-18 years) took part...
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The Nose-Brain Pathway: Exploring the Role of Trigeminal Nerves in Delivering Intranasally Administered Antidepressant
In a recent study, Japanese scientists have developed a novel concept of a nose-to-brain system for the clinical application of neuropeptides. They developed a derivative of glucagon-like peptide-2 and found that when administered intranasally, it is efficiently delivered through the trigeminal nerve to the site of action and exhibits antidepressant-like effects. This is the first...
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How repairing the gut saves brain function after stroke
by Heather Lander, Texas A&M University Effect of IESC transplants on gut architectures after stroke. a) Representative photomicrographs of H & E stained sections (10 µm) from sham, MCAo-vehicle treated and MCAo-IESC treated adult female and male rats. In all groups, sham animals (a-left panels) exhibit elongated normal villi and a single row of crypts, while...
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Newly developed gene classifier identifies risk of pre-breast cancer progression
by Duke University Medical Center Cohorts and methods outline. Two retrospective study cohorts were generated, consisting of ductal carcinoma in situ (DCIS) patients with either a subsequent ipsilateral breast event (iBE) or no later events after surgical treatment. TBCRC samples were macrodissected for downstream RNA and DNA analyses. RAHBT samples were (1) macrodissected like TBCRC...
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Study reveals the intrinsic immune mechanism that boosts axon regeneration in the adult nervous system
by Hong Kong University of Science and Technology In CNS, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates neuronal cGAS expression. cGAS produces cGAMP and activate STING in neurons. In PNS, such as dorsal root ganglion, axotomy induces IFNγ expression in axons by local translation. And IFNγ activates...
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How monoclonal antibodies lost the fight with new COVID variants
PIEN HUANG Antonio Rapuano got an infusion of a monoclonal antibody to treat his COVID in Albano, Italy in 2021. Such infusions have been effective treatments for COVID during the pandemic, but doctors are now finding that most monoclonal antibodies no longer work against new variants of SARS-CoV-2. Yara Nardi/Reuters Monoclonal antibodies were once the...
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Pain Relievers Like Ibuprofen and Naproxen May Worsen Arthritis Inflammation
By RADIOLOGICAL SOCIETY OF NORTH AMERICA NOVEMBER 21, 2022 According to new research, taking anti-inflammatory pain relievers like ibuprofen and naproxen for osteoarthritis may actually worsen inflammation in the knee joint over time. Taking anti-inflammatory pain relievers like ibuprofen and naproxen for osteoarthritis may worsen inflammation in the knee joint over time. This is according to a...
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Provention prices diabetes drug above analysts’ estimates at $13,850/vial
By Raghav Mahobe and Nandhini Srinivasan Nov 18 (Reuters) – Provention Bio Inc (PRVB.O) has priced its diabetes drug teplizumab at $13,850 a vial, it said on Friday, a day after receiving U.S. approval and far higher than some analysts’ expectations. The company’s shares reversed course from premarket gains to trade down nearly 12% as the high pricing stoked fears...
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Experimental fentanyl vaccine stops the drug from entering the brain
By Ben Coxworth November 15, 2022 Fentanyl is one of the most potent opioids, and is therefore one of the most lethal when taken in excessDepositphotos Even when someone is determined to beat their fentanyl addiction, there’s still a good chance they will relapse at some point, and start taking the opioid again. A new...