by The Hospital for Sick Children Graphical abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.10.009 Researchers from The Hospital for Sick Children (SickKids) have uncovered new genes and genetic changes associated with autism spectrum disorder (ASD) in the largest autism whole genome sequencing analysis to date, providing better understanding into the ‘genomic architecture’ that underlies this disorder. The study,...
By MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING NOVEMBER 7, 2022 Scientists found that worms live longer if introns remain in certain RNAs. The study found that faulty RNA processing can result in longer life. RNA is an important information transmitter in our cells and acts as a blueprint for protein production. When freshly formed RNA is processed,...
While it is unlikely, a person may alternate between hyperthyroidism and hypothyroidism. This depends on the balance of thyroid antibodies present in autoimmune thyroid disorders. The thyroid is a butterfly-shaped gland at the base of the front of a person’s neck. It secretes hormones that help to control vital body functions. Hypothyroidism happens when the...
Neuropathy involves damage to the nerves. In some cases, people with hyperthyroidism may develop neuropathy. This article explores the link between hyperthyroidism and neuropathy, other common causes of neuropathy, and additional neurological symptoms of hyperthyroidism. Can hyperthyroidism cause neuropathy? Kelly Knox/Stocksy Hyperthyroidism involves an excess, or overproduction of, thyroid hormones. This can lead to symptoms such as: irritability rapid...
The annual global death toll from long-term exposure to fine particulate outdoor air pollution may be significantly higher than previously thought, according to a new study. That’s because mortality risk was increased even at very low levels of fine particulate outdoor air pollution, ones which had not previously been recognized as being potentially deadly. These...
NATIONAL UNIVERSITY OF SINGAPORE, YONG LOO LIN SCHOOL OF MEDICINE Multiple sclerosis (MS) is an autoimmune disease affecting the brain and spinal cord. In MS, the activated immune cells attack myelin, a protective layer surrounding nerve cells, which disrupts the transmission of nerve impulses along nerve cells. Over time, there is permanent damage or deterioration...
UNIVERSITY OF CALIFORNIA – RIVERSIDE IMAGE: PET SCAN IMAGES SHOW ORALLY ADMINISTERED EPP6 ACCUMULATED IN THE INTESTINES AND MADE ITS WAY INTO THE BRAIN AND BLADDER THROUGH BLOOD CIRCULATION. CREDIT: MIN XUE/UCR Researchers at UC Riverside are paving the way for diabetes and cancer patients to forget needles and injections, and instead take pills to...
CHALMERS UNIVERSITY OF TECHNOLOGY IMAGE: THE RED CANCER CELL USES THE WHITE PROTEIN MEMO1 TO BIND THE GREEN COPPER IONS. CREDIT: YEN STRANDQVIST, CHALMERS UNIVERSITY OF TECHNOLOGY For cancer cells to grow and spread around the human body, they need proteins that bind copper ions. New research about how cancer-related proteins bind the metal and...
UNIVERSITY OF VIRGINIA HEALTH SYSTEM IMAGE: UVA HEALTH’S JEFF ELIAS, MD, HAS PIONEERED THE USE OF FOCUSED ULTRASOUND FOR CONDITIONS THAT INCLUDE ESSENTIAL TREMOR. CREDIT: UVA HEALTH A scalpel-free, high-tech form of brain surgery pioneered at UVA Health offers long-term relief for patients with essential tremor, a common movement disorder, a five-year review shows. The study...
by University of California, San Francisco Generation and screening of a pooled library of CARs with diverse signaling domains. (A) Our CARs combine an αCD19 ScFv (FMC63), a CD8 hinge and transmembrane domain (TMD), an intracellular signaling domain, and a CD3ζ domain (left). Forty domains from across the human proteome were codon-optimized, synthesized, pooled into...
