by Netherlands Institute for Neuroscience White noise (WN) is an aversive stimulus that lowers dopamine concentration in the nucleus accumbens core (NAC). (A) Left: example trajectory of a rat in the real-time place aversion test (30 min), in which entry into one quadrant (shaded), which was randomly determined prior to the session, led to 90...
by Ian Haydon, University of Washington School of Medicine Neoleukin-2/15 can be split into two fragments that reconstitute its activity when combined. a, Splitting strategy for Neo-2/15. Structure of Neo-2/15 (cylinder representation) and murine IL-2 receptors β and γ (beige and pink surface representations, respectively, PDB ID: 6dg5). Dashed line represents the selected split site...
by University of Pittsburgh Human chromosomes (gray) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASA Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality. In a paper published in Science this week, Jonathan Alder, Ph.D. and his team describe how they discovered...
by Public Library of Science Researchers find long-term physical and mental health outcomes after COVID-19 occur in all ages. Credit: Kelly Sikkema, Unsplash (CC0, creativecommons.org/publicdomain/zero/1.0/) Following COVID-19 infection, there is significant new onset morbidity in children, adolescents and adults across 13 distinct diagnosis and symptom complexes, according to a new study publishing November 10 in the...
by Queen Mary, University of London Inhibition of FGFR1 limits invasion in pre-clinical models of PDAC. A Representative H&E images of MIA PaCa-2: PS1 organotypics treated with 100 nM Gemcitabine, 1 μM ATRA, or 1 μM AZD4547 either alone or in combination for 7 days. B Quantification of invasion from A. Images representative of at least 3 biological repeats. Individual colors on graphs indicative...
by The City University of New York Credit: Pixabay/CC0 Public Domain The use of electronic cigarettes is increasing, especially among young people. In the U.S., outbreaks of lung injury and other respiratory illnesses and deaths associated with vaping have been reported, but the short- and long-term health implications are largely unknown. In a new study...
PRINCETON UNIVERSITY IMAGE: BACTERIAL GENES KGRA-E, SHOWN AS ARROWS AT THE TOP, ENCODE FOR THE ENTEROPEPTIN PRECURSOR PEPTIDE AND FOUR TAILORING ENZYMES. THESE ENZYMES MODIFY THE CORE AND REMOVE THE LEADER AND FOLLOWER SEGMENTS OF THE PRECURSOR TO PRODUCE ENTEROPEPTIN A. CREDIT: NATURE CHEMISTRY Researchers in the Princeton University Department of Chemistry have discovered a new multi-step...
by Keck School of Medicine of USC The “life cycle” of an mRNA in a eukaryotic cell. RNA is transcribed in the nucleus; processing, it is transported to the cytoplasm and translated by the ribosome. Finally, the mRNA is degraded. Credit: Public Domain While vaccination can provide life-saving protection against COVID-19, scientists are still searching...
by Li Yuan, Chinese Academy of Sciences Distribution of NAcBLA and NAcPVT neurons in the NAc. Credit: SIAT Reward-seeking and threat avoidance are critical for survival. Pursuing enjoyable things triggers the release of dopamine in the brain, making people feel pleasure. In contrast, people subconsciously avoid unpleasant feelings such as hunger, nausea and pain in order to...
by Karen Weintraub Credit: Unsplash/CC0 Public Domain Personalized care has been a buzzword in medicine for years, but new research on cancer treatment is taking it to a new level. Detailed in a study published Thursday in Nature, the new approach combines several cutting-edge technologies to provide perhaps “the most complicated” treatment ever given. But by...
