by Telethon Kids Institute Three-year-old Bull Terrier, Maggie, is about to undergo surgery using the immunotherapy gel to treat her sarcoma. It is hoped the world-first clinical trial in dogs will be a vital step towards developing the immunotherapy gel in children and adults with Sarcoma. Credit: Telethon Kids Institute Telethon Kids Institute is leading...
How high blood sugar REALLY causes type 2 diabetes
By JOE DAVIES HEALTH REPORTER FOR MAILONLINE PUBLISHED: 05:00 EST, 14 November 2022 | UPDATED: 07:27 EST, 14 November 2022 For decades, scientists have been puzzled over how exactly high blood sugar causes type 2 diabetes. But Oxford University researchers may finally have the answer. Tests revealed it wasn’t the elevated glucose levels that were directly to blame for...
An innovative ‘smart mask’ with a use beyond pandemics
by Andrew Johnston, IMDEA Materials IMDEA Materials Visiting Researcher Dr. José Sánchez del Río Sáez shows off a prototype of the smart mask sensor. Credit: Andrew Johnston, IMDEA Materials Institute A group of researchers in the Madrid region have developed and patented a new smart mask with an innovative design that can monitor a wearer´s...
Monitoring Congestive Heart Failure Through Speech: Interview with Tamir Tal, CEO of Cordio Medical
NOVEMBER 11TH, 2022 CONN HASTINGS CARDIOLOGY, DIAGNOSTICS, EXCLUSIVE Cordio Medical, a medtech company based in Israel, has developed HearO, an app that can assist in monitoring congestive heart failure. The technology is based on the phenomenon whereby congestive heart failure patients demonstrate changes in their voice as their disease progresses or in advance of disease exacerbation....
Oral deucravacitinib benefits patients with lupus
by Wiley Credit: CC0 Public Domain Tyrosine kinases are enzymes that play central roles in signaling by cytokines involved in the pathogenesis of autoimmune diseases, including lupus. A recent phase 2 clinical trial published in Arthritis & Rheumatology has generated promising results for deucravacitinib, an oral inhibitor of tyrosine kinase 2 (TYK2), in patients with active lupus....
How COVID-19 causes neurological damage
by University of Basel Neuro-COVID patients display a vigorous peripheral immune response and specific CSF alterations including analytes with high predictive value for class III development and strong CSF-plasma correlation. a Rose plots representing Z-scores of marginalized normalized protein expression (NPX) of 192 soluble proteins in CSF and plasma. For better visualization, analytes have been grouped into...
Anifrolumab shows long-term promise in patients with lupus
by Wiley Credit: CC0 Public Domain Type I interferon (IFN) is a powerful immune activator that is present at high levels in the majority of patients with lupus, an autoimmune disease. In Arthritis & Rheumatology, researchers report positive results from the first placebo-controlled long-term trial of anifrolumab—a human monoclonal antibody that targets the type I IFN...
Repeat COVID infections increase risk of health problems: study
by Daniel Lawler Researchers have urged people to wear masks this holiday season after finding that multiple Covid infection increases the risk of health issues. People who have had COVID more than once are two or three times more likely to have a range of serious health problems than those who have only had it...
HSS research uncovers how UV light triggers immune activation and disease flares in lupus
HOSPITAL FOR SPECIAL SURGERY After sun exposure, people with systemic lupus erythematosus (SLE) frequently develop skin rashes, which often are accompanied by a flare of their overall disease. This connection between ultraviolet (UV) light and disease flares in lupus is well known, but the way in which UV exposure actually triggers the disease has been...
Efficient mRNA delivery by branched lipids
HOKKAIDO UNIVERSITY IMAGE: A CROSS-SECTION OF AN LNP-RNA. THE MRNA (RED) IS ENCAPSULATED BY LIPIDS (BLUE SPHERES WITH TAILS; IMAGE: YUSUKE SATO). CREDIT: YUSUKE SATO Messenger RNA (mRNA) are biological molecules that transfer the information coded by genes in the nucleus to the cytoplasm for protein synthesis by ribosomes. mRNA sequences can be designed to...