by The Scripps Research Institute Cancer cell during cell division. Credit: National Institutes of Health Scientists at Scripps Research have uncovered a critical feature that a promising new class of cancer drugs, known as CELMoDs, needs to be effective. CELMoDs are designed to attack cancer in a novel way, by binding to a regulatory protein called cereblon, which...
by Radboud University Nijmegen Credit: Pixabay/CC0 Public Domain It’s not the individual brain regions but rather their connections that matter. Neuroscientists propose a new model of how the brain works. This new view enables us to understand better why and how our brains vary between individuals. The researchers have published their work in a special...
NOVEMBER 8TH, 2022 CONN HASTINGS MATERIALS, MEDICINE, NANOMEDICINE, ONCOLOGY Scientists at the University of Eastern Finland have developed a technique that lets them improve the coating of nanoparticles when using cell membranes. Cell membranes offer a lot of benefits as a coating for synthetic nanoparticles, including shielding from the immune system, prolonged circulation times and...
NOVEMBER 8TH, 2022 CONN HASTINGS ENT, PEDIATRICS, TELEMEDICINE Researchers at the University of Washington have developed a low-cost hearing test for newborns. Traditionally, the equipment for such testing is quite expensive. As newborns cannot let us know if they can hear something, the test is based on creating a noise within the ear canal and then...
KANAZAWA UNIVERSITY IMAGE: © 2022 SAKAI, ET AL. (A) A PHARMACOPHORE SEQUENCE OF MET RECEPTOR-BINDING MACROCYCLIC PEPTIDE (AMD4; SHOWN IN RED) WAS INSERTED INTO THE LOOPS (COLOURED BALLS) OF HUMAN IGG1 FC PROTEIN. (B) LASSO-GRAFTING FC YIELDS MET AGONISTS WITH EXTENDED HALF-LIFE IN THE BODY. (C) LASSO-GRAFTING FC OF AN ANTI-TFR ANTIBODY YIELDS MET AGONISTS...
HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES IMAGE: MAGNETIC NAVIGATION OF MAGNETOTACTIC BACTERIAL AND THE MAGNETOSOME CHAINS. CREDIT: MA KUN In a paper published in Proceedings of the National Academy of Sciences of the United States of America (PNAS) recently, a team led by Prof. WANG Junfeng from the High Magnetic Field Laboratory (HMFL), Hefei Institutes of...
by Indiana University School of Medicine Accelerated plaque deposition in 5xFAD mice deficient in Cx3cr1. (A) Accumulation of MOAB2+ Aβ42 plaques in (top panels) 4 month-old vs. (bottom panels) 6 month-old 5xFAD;Cx3cr1+/+ and 5xFAD; Cx3cr1−/− mice. Scale bars = 500 μm. Quantification of %MOAB2+ areas in the (B) cortex and (C) hippocampus of 4 and 6 month-old 5xFAD;Cx3cr1+/+ (black bars) and 5xFAD;Cx3cr1−/− (gray bars) mice. Data in B,C represent...
by Michael McCarthy., University of Washington Three-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Center for Cancer Research, National Cancer Institute, National Institutes of Health An experimental vaccine against breast cancer safely generated a strong immune response to a key...
AARHUS UNIVERSITY “Breathe in… Breathe out…” Or: “take a deep breath and count to ten.” The calming effect of breathing in stressful situations, is a concept most of us have met before. Now Professor Micah Allen from the Department of Clinical Medicine at Aarhus University has come a step closer to understanding how the very...
by University of Cambridge Credit: Pixabay/CC0 Public Domain People who have a past history of hospitalization because of substance use disorders have much worse outcomes following the onset of a wide range of physical health conditions, according to researchers in the UK and Czechia. In a study published today in The Lancet Psychiatry, researchers looked at the...
