by Dalhousie University Thiopurines 6-thioguanine and 6-thioguanosine inhibit coronavirus replication. (A) Structures of thiopurines used this study in comparison to guanine. (B) Calu-3 cells were infected with SARS-CoV-2 at an MOI of 0.1 then treated with 6-thioguanine (6-TG), 6-thioguanosine (6-TGo), or 6-mercaptopurine (6-MP). Supernatants were harvested after 48 h and stored at -80°C until titering...
by JooHyeon Heo,Ulsan National Institute of Science and Technology EM-based subcutaneous implant glucose sensor. (a) Illustration of EM-based implantable sensor for BGL tracking; (1) blood capillary (2) electromagnetic sensor (3) dermis (4) subcutaneous fat (5) muscle tissue. (b) Proposed implant sensor. (c) Sensor size (15 mm × 4 mm ∅) compared with a coin. (d) Sensor frequency...
by King’s College London Credit: CC0 Public Domain When we consume fats (also called lipids) in our diet, they can be metabolized or stored to provide energy for the body. But they are also involved in regulating the genes expressed within—and the signaling between—cells. Lipids influence how our cells behave and function, which affects many...
by Karolinska Institutet Credit: CC0 Public Domain Researchers at Karolinska Institutet in Sweden have identified the bacteria most commonly found in severe oral infections. Few such studies have been done before, and the team now hopes that the study can provide deeper insight into the association between oral bacteria and other diseases. The study is...
by Julia Evangelou Strait, Washington University School of Medicine A drug compound stimulates immune cells to attack prostate tumors, according to new research from Washington University School of Medicine in St. Louis. Shown is a human prostate cancer organoid, a small 3D structure that serves as a model of prostate tumors. When the organoid is...
by Duke University Medical Center Schematic of the tumor-intrinsic NLRP3-HSP70 signaling axis and its role in supporting metastatic progression in the lung in response to anti-PD-1 immunotherapy. Credit: B. Theivanthiran, et al., Science Translational Medicine (2022) Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma...
by Hayley Jarvis, Brunel University Credit: Brunel University Sugar substitutes found in many supermarket foods have been shown to kill off antibiotic-resistant bacteria that cause pneumonia and sepsis. Three artificial sweeteners used in products such as diet drinks, yogurts and desserts dramatically halt the growth of multidrug-resistant priority pathogens. The additives not only disable bacteria...
by Bob Yirka, Medical Xpress Credit: Contraline A team of researchers at a company called Contraline has developed a new kind of male contraceptive. Instead of using hormones to disrupt sperm production, the new technique involves placing a hydrogel called ADAM into the vas deferens to prevent sperm from making its way to the urethra....
by CU Anschutz Medical Campus a, Diagram of trial design. b, Summary of pathological outcomes of all evaluable patients (n = 19 patients). c, Summary of clinical outcomes of patients treated at MTD (n = 18). d, Kaplan–Meier survival curves for overall survival, PFS and local PFS survival for patients treated at MTD (n = 18 patients). e, A plot of...
by University of Illinois at Chicago Credit: CC0 Public Domain A new study published in JAMA Internal Medicine suggests that women over the age of 65 may be undergoing unnecessary cervical cancer screenings and that more public health data is needed on the utilization of cervical cancer screening-associated services among older women to prevent potential harm and...
