by Queen Mary, University of London Noncoding mutations impacting BCL genes. a, Genome view of BCL2 5′ UTR. The significantly mutated region is indicated by a black rectangle. Individual somatic mutations are shown in blue. b, Gene expression of BCL2 in TPM determined by RNA-seq in samples with BCL2 5′ UTR mutations versus WT. Black dots are...
by Sarah Avery, Duke University Credit: Unsplash/CC0 Public Domain In a head-to-head comparison of two so-called “water pills” that keep fluid from building up in patients with heart failure, the therapies proved nearly identical in reducing deaths, according to a large study led by Duke Health researchers. The study compared the diuretics torsemide and furosemide...
by Anne Manning, Colorado State University Credit: Pixabay/CC0 Public Domain Since the start of her career, Jennifer DeLuca has been fascinated by mitosis, the everyday biological process of cell division: how it works, which proteins and cellular machineries are involved, and why it sometimes goes wrong and leads to disease. About a decade ago, the...
by University of Bonn Single variant exome-wide association study Manhattan plot (MAF>0.1%). QQ-plot available in the S1 Fig. Black dashed line demarcates the genome-wide significance threshold (p < 5×10-8). Credit: PLOS Genetics (2022). DOI: 10.1371/journal.pgen.1010367 Rare gene mutations can significantly increase the risk of severe COVID-19 disease. An international research team with significant contribution from the University...
IMAGE SOURCE, NHSBT Image caption, The lab-grown blood kept in a facility in BristolBy James GallagherHealth and science correspondent Blood that has been grown in a laboratory has been put into people in a world-first clinical trial, UK researchers say. Tiny amounts – equivalent to a couple of spoonfuls – are being tested to see...
Faith GeigerMon, November 7, 2022 at 3:00 AM woman holding plate of toast and checking watch It’s impossible to overstate the importance of a healthy breakfast when it comes to weight loss. The right breakfast will give you the energy you need to take on the day, smash your workouts, and burn calories in order to kick...
By Jamie Gumbrecht, CNN Published 4:10 PM EST, Sun November 6, 2022 Paxlovid, the antiviral pill that reduces the risk of hospitalization and death from Covid-19, also reduces the risk of long Covid, according to a new study by researchers at the US Department of Veterans Affairs. The study, posted online as a preprint on Saturday, analyzed...
November 6, 2022 6:00 PM ET ALLISON AUBREY Millions of Americans are prescribed statins to reduce the risk of heart disease, but many prefer to take supplements like fish oil, garlic and flaxseed. Peter Dazeley/Getty Images If you were prescribed medicine to lower your risk of a heart attack or stroke, would you take it?...
by Melissa Rohman, Northwestern University Credit: Unsplash/CC0 Public Domain Northwestern Medicine investigators have discovered the mechanisms by which a particular protein promotes cancer cell proliferation and survival in acute myeloid leukemia (AML), according to a Northwestern Medicine study published in Blood. The findings suggest that PRL2, a protein tyrosine phosphatase, may be a novel therapeutic target for AML, according...
In the Chinese population, the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the total cholesterol (TC)/HDL-C ratio are associated with an increased risk for benign prostatic hyperplasia (BPH), according to a study published online Oct. 3 in Frontiers in Nutrition. Chen Zhu, from The First Affiliated Hospital with Nanjing Medical University in China, and colleagues...
