Month: <span>November 2022</span>

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Newly designed molecule could help treat deadly lung condition
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Newly designed molecule could help treat deadly lung condition

by Isabella Backman, Yale University Overview of modifications differentiating second-geneneration miR-29 from first gen MRG-201/Remlarsen. Top, first-gen MRG-201, the parent compound, bottom, MRG-229 (Next generation miR-29 mimic), the second-gen compound. DNA bases: white circles = unmodified base, blue circles = 2’OMe, purple circles = 2’F, linkages: green circles = phosphorodiester linkage, orange circles = phosphorothioate (PS) linkage. NH2 terminus modification: MRG-201/Remlarsen = cholesterol, BiPPB = platelet-derived growth factor beta...

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Some great benefits of Jointly Useful Relationships – Older Men Dating Sites For In search of Younger Women

A jointly beneficial romantic relationship can be a advantage to both parties. Typically, this will likely occur the moment two entities are drawn to each other’s business model and agree to assist each other over a specific job or motivation. The stipulation will include both equally partners giving voice their respective demands and acquiescent to...

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NIH-funded study finds personalized kidney screening for people with type 1 diabetes could reduce costs, detect disease earlier

NIH/NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES Taking a personalized approach to kidney disease screening for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease (CKD) goes undetected, according to a new analysis performed by the Epidemiology of Diabetes Interventions and Complications study group, which is funded by...

Study offers new insights into genetic mutations in autism disorders and points to possible treatments
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Study offers new insights into genetic mutations in autism disorders and points to possible treatments

by Timothy Dean, The Geisel School of Medicine at Dartmouth Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111574 Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth’s Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the...

Study offers proof of concept for treating pediatric brain tumors with immunotherapy
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Study offers proof of concept for treating pediatric brain tumors with immunotherapy

by Children’s Hospital of Philadelphia  GPC2 is expressed in pediatric brain tumors. (A) GPC2 RNA sequencing data across OpenPBTA pediatric brain tumors cohorts. Neuroblastoma GPC2 RNA sequencing included for comparison on the left. (B) Using a cut-off value of 10 TPM, percentage of tumors in the OpenPBTA dataset with high expression of GPC2. (C) RNA...

Study: First-degree relatives of patients with NAFLD are at risk of liver disease
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Study: First-degree relatives of patients with NAFLD are at risk of liver disease

by University of California – San Diego Credit: Pixabay/CC0 Public Domain Approximately one-fourth of the general population worldwide has nonalcoholic fatty liver disease, known as NAFLD, an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. NAFLD can lead to cirrhosis, liver cancer and liver failure. In a...

Iron induces chronic heart failure in half of heart attack survivors, according to new study
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Iron induces chronic heart failure in half of heart attack survivors, according to new study

by Indiana University School of Medicine An overarching model of how hemorrhagic infarction promotes chronic heart failure via fat deposition. a) Following MI, compensatory remodeling promotes partial recovery of LV function in the early weeks following the index event. In hemorrhagic infarction, the extravasated red blood cells promote active inflammation and participate in the formation...