disease A recent study showed that itanapraced disrupted genetic mutations associated with Parkinson’s disease and reduced loss of neurons in cell culture and mouse models. ImagesBazaar/Getty Images Mutations that enhance the activity of the LRRK2 enzyme are one of the most common mutations in inherited and sporadic Parkinson’s disease. A recent study showed that mutations...
EUROPEAN ALLIANCE OF ASSOCIATIONS FOR RHEUMATOLOGY (EULAR) SAIDs are a group of multi-system disorders caused by dysfunction in the innate immune system. A number of these SAIDs are mediated by a cytokine called interleukin-1 (IL-1), including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), and deficiency of...
CELL PRESS The urge to vomit after eating contaminated food is the body’s natural defensive response to get rid of bacterial toxins. However, the process of how our brain initiates this biological reaction upon detecting the germs remains elusive. For the first time, researchers mapped out the detailed neural pathway of the defensive responses from...
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE IMAGE: A-TO-I EDITING FUNCTIONS MUCH LIKE A LARGE-SCALE CUT AND PASTE TYPE OF EDIT ON PRE-MRNA SEQUENCES, DRIVEN BY ADAR ENZYMES. IN THE BRAIN, THESE NATURAL MODIFICATIONS HAVE DIVERSE EFFECTS ON GENE EXPRESSION AND PROTEIN FUNCTION THROUGHOUT NEURODEVELOPMENT. CREDIT: JESSICA JOHNSON Mount Sinai researchers have...
LIEBER INSTITUTE FOR BRAIN DEVELOPMENT Baltimore, Md. (November 1, 2022) – Researchers at the Lieber Institute for Brain Development(LIBD) believe they have solved a riddle that has challenged scientists for more than 70 years: how the brain chemical dopamine relates to schizophrenia, the often-devastating brain disorder characterized by delusional thinking, hallucinations and other forms of psychosis. Through...
THE HOSPITAL FOR SICK CHILDREN In a ground-breaking new study, scientists have uncovered the mechanics of the blood-tumour barrier, one of the most significant obstacles to improving treatment efficacy and preventing the return of cancerous cells. The research team, led by Dr. Xi Huang, a Senior Scientist in Developmental & Stem Cell Biology program at The Hospital for Sick...
by Jennifer Michalowski, Cold Spring Harbor Laboratory Researchers used the brain mapping technology, BARseq, to study hundreds of neurons at a time in the mouse olfactory bulb. In this tissue section of a mouse olfactory bulb, different colors denote different barcoded neurons. Credit: CSHL, 2022 Our sense of smell has a powerful effect on our...
by Margaret Osborne, Cold Spring Harbor Laboratory Hypothetical read-out mechanisms of the counting neuron. A) This model translates the continuous firing rate of the 1-2-3-many counter neuron into a discrete representation. Because this model uses repetition suppression, larger firing rates correspond to less familiar odors. The counter synapses onto four downstream neurons, each with succcessively...
by University of Manitoba The figure shows the associations between PRSs for major depression, bipolar disorder, and schizophrenia and outcomes of ECT among all participants (main analysis) and among only those with unipolar depression (sensitivity analysis). Odds ratios are per standard deviation of increasing PRS, and an oddsratio .1 indicates higher odds of favorable outcome....
by University of California – San Diego A scanning electron micrograph depicts a clump of prostate cancer cells. Credit: Cell Image Library Tapping into the Million Veteran Program, an ongoing national research effort to learn how genes, lifestyle and military exposures affect the health of participants, researchers at University of California San Diego School of...
