by Dana-Farber Cancer Institute Graphical Abstract. Credit: Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.02.026 Custom-made to attack cancer cells, CAR T-cell therapies have opened a new era in the treatment of human cancers, particularly, in hematologic malignancies. All too often, however, they display a frustrating trait inherited from the body’s own immune system cells: a drastic loss of cancer-fighting...
by Ben-Gurion University of the Negev Skeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domain Statins are the most commonly used medication in lowering blood cholesterol, prescribed to tens of millions in the Western world. Statins act through inhibition of the enzyme HMG CoA reductase. Nearly 20% of statin users develop...
by University of Bonn If the mitochondria (light blue) are damaged, the NLRP10 “smoke detector” sounds the alarm and forms with other proteins into an inflammasome (red). Ultimately, this leads to the demise of the cell and its disposal. Credit: Kim S. Robinson/Skin Research Institute Singapore Researchers at the Universities of Bonn and Singapore have discovered a new...
by The Hospital for Sick Children A platform for clustering and classification of RNA-seq data. a, Schematic representation of the steps involved in our RNA-seq tumor subtype identification protocol. We first built an extensive reference hierarchy of tumor and normal subtypes using RACCOON, a novel scale-adaptive clustering framework. This hierarchy was then used as a...
by University Medical Center Utrecht Electrode positions, fiber tracts and evoked potentials. a, MNI brain surface showing white matter tracts and electrode positions at endpoints from all 74 subjects. b, CCEPs from young subjects (black lines, 4, 7 and 8 years old) and older subjects (blue lines, 26, 34 and 35 years old) across the SLF frontal-parietal tract after...
by Institute for Systems Biology Credit: Pixabay/CC0 Public Domain Institute for Systems Biology (ISB) researchers have constructed biological body mass index (BMI) measures that offer a more accurate representation of metabolic health and are more varied, informative and actionable than the traditional, long-used BMI equation. The work was published in the journal Nature Medicine. For decades, clinicians have...
UNIVERSITY OF CALIFORNIA – BERKELEY IMAGE: BIOLOGICAL FLUIDS ARE MADE UP OF HUNDREDS OR THOUSANDS OF DIFFERENT PROTEINS (REPRESENTED BY SPACE FILLING MODELS ABOVE) THAT EVOLVED TO WORK TOGETHER EFFICIENTLY BUT FLEXIBLY. UC BERKELEY POLYMER SCIENTISTS ARE TRYING TO CREATE ARTIFICIAL FLUIDS COMPOSED OF RANDOM HETEROPOLYMERS (THREADS INSIDE SPHERES) WITH MUCH LESS COMPLEXITY, BUT WHICH...
TOKYO MEDICAL AND DENTAL UNIVERSITY CREDIT: DEPARTMENT OF NEPHROLOGY, TMDU Researchers from Tokyo Medical and Dental University (TMDU) have uncovered a link between cardiovascular disease and chronic kidney disease, revealing novel disease biomarkers and therapeutic targets Tokyo, Japan – Chronic kidney disease is linked to the formation of mineral deposits on blood vessel walls, known as...
By Bronwyn Thompson March 19, 2023 Scientists unlock more of the genetic code behind depression Depositphotos Depression is incredibly complex, highly individual and most often linked to a cache of other triggers and comorbidities. But in 2021, a look at 1.2 million people found 178 gene variants linked to major depressive disorder (MDD) and confirmed that our...
By Ben Coxworth March 17, 2023 From left, Prof. Benu Adhikari, Dr. Thilini Thrimawithana and PhD candidate Manisha Singh, with roselle flower petals RMIT University For some people who are morbidly obese, changes in diet and lifestyle just aren’t sufficient to shed all the extra weight. A new study suggests that a hibiscus flower extract...
